通膝散对急性高尿酸血症小鼠血尿酸的影响

目的 考察通膝散对急性高尿酸血症小鼠的降血尿酸作用。方法 实验分成模型组，别嘌呤醇（10 mg/kg）阳性对照组，通膝散高、中、低剂量（500、300、100 mg/kg）组。除模型组外，其他各组小鼠每天给予相应药物1次，连续给药3 d，末次给药后2 h ip尿酸（450 mg/kg）建立小鼠急性高尿酸血症模型，80 min后检测血尿酸水平。结果 与模型组相比，通膝散高、中剂量组可显著降低小鼠血尿酸水平（P＜0.01），别嘌呤醇也有显著作用（P＜0.01），通膝散高剂量的作用强度与别嘌呤醇相当。结论 通膝散对小鼠急性血尿酸升高具有抑制作用。

Effect of Tongxi Powder on blood uric acid of mice with acute hyperuricemia

Objective To investigate the effect of Tongxi Powder (TP) on decreasing the uric acid of mice with acute hyperuricemia. Methods The mice were divided into model, allopurinol (positive control, 10 mg/kg), low-, mid-, and high-dose (100, 300, and 500 mg/kg) TP groups. Except the model group, mice in other groups were administered once daily for 3 d. The acute hyperuricemia model of mice was established 2 h after the last administration and then ip uric acid (450 mg/kg), and the blood uric acid contents were determined after 80 min. Results Compared with the model group, TP at mid- and high-dose could obviously decrease the blood uric acid level in mice (P < 0.01), so did allopurinol (P < 0.01). The effect of high-dose TP group was the same as that of allopurinol group. Conclusion TP could inhibit the increase of blood uric acid in mice with acute hyperuricemia.