Is 3,4-dihydroxyphenylglycol the major route of central norepinephrine metabolism in rat brain? |
| |
| Authors: | F Karege J M Gaillard |
| |
| Affiliation: | 1. American Heart Association – Tobacco Regulation and Addiction Center, Superfund Research Center and Diabetes and Obesity Center, Institute of Molecular Cardiology, University of Louisville, 580 South Preston Street, Louisville, KY, 40202, United States of America;2. Department of Chemistry, University of Louisville, 2320 S. Brook St., Louisville, KY, 40292, United States of America;1. Division of Neuropsychopharmacology, Department of Psychology, Estonian Centre of Behavioural and Health Sciences, University of Tartu, Estonia;2. Psychiatry Clinic, North Estonia Medical Centre, Tallinn, Estonia;3. Department of Neuroscience, Pharmacology, University of Uppsala, Biomedical Centre, Uppsala, Sweden;1. School of Clinical Medicine, Weifang Medical University, Baotong West Street 7166, Weifang, China;2. Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, 20 East Yuhuangding Road, Yantai, Shandong 264000, China;3. Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, 20 East Yuhuangding Road, Yantai, Shandong 264000, China |
| |
| Abstract: | Central norepinephrine (NE) metabolism was assessed by measuring 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG) and 3,4-dihydroxyphenylethyleneglycol (DHPG) in different rat brain areas after saline or probenecid (300 mg/kg) administration. Under probenecid, results showed an increased accumulation of total MHPG and DHPG, and a clear preponderance of DHPG levels over MHPG in almost all the brain areas examined. Estimation of their formation rates confirmed that in basal conditions DHPG is formed more rapidly. This study supports the notion that, without ruling out the importance of MHPG, brain DHPG may be a useful index of central NE activity. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
