棉尘致纤维化作用的实验研究

80mg梳棉尘及代表其主要成份的脱脂棉尘80mg,含革兰氏阴性菌:取自100mg梳棉尘的提取液和4mg SiO_2间断、分次分组染尘大鼠1天至12月后病理观察表明:脱脂棉尘最初引起急性间质性炎症,继而形成异物型肉芽肿,至12月发展为纤维性细胞结节及病损区间质一定程度的纤维化,仅逊于梳棉尘组的严重程度,提取液和微量SiO_2不能造成广泛肺损伤,各染尘组BAL细胞成份变化趋势与病理改变同步,提示棉纤维所致异物性炎症是肺间质病变的主因.

An Experimental Study on Fibrogenic Effect of Cotton Dust

Pathologic changes were observed from 1 day to 12 months after repeatedintratracheal injection into rats'lungs with carded cotton dust(CD,total 80mg),ab-sorbent cotton dust(ACD,80mg),extract of CD containing Gram negative bacteria(ECD,extracted from 100mg CD)and 4mg quartz.The result showed that ACD in-duced acute interstitial inflammation of the lungs at the first day,followed by the ap-pearance of foreign-body-type granulomas.BY the end of 12th month they devel-oped to a certain extent into fibrostic cellular nodes and interstitial fibrosis in the af-fected area,but all the above changes were less serious than that caused by CD.ECDand small amount of quartz could not lead to serious damage of the lung tissue.Thechanging trend of cell's total and proportion in the bronchoalveolar lavage was syn-chronized with histologic changes in different dust-injected groups,it is suggestedthat foreign-body inflammation caused by cotton fibre might be the main factor re-sulting in lungs interstitial lesion.