Subclassification of microsatellite-unstable tumors in colorectal cancer |
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Authors: | Nita Ahuja Stephen B Baylin |
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Institution: | (1) Johns Hopkins University, 1650 Orleans Street, CRB1, Room 342, Baltimore, MD 21231, USA |
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Abstract: | Hereditary nonpolyposis colorectal cancer (HNPCC) is an inherited syndrome with a germline mutation in the mismatch repair
(MMR) genes. Microsatellite instability is found in most of these tumors, but it also appears in 15% to 20% of all sporadic
colorectal cancers. Although the phenotype in both these cancers is the same, the genotype is different. In HNPCC tumors,
MMR errors are due to an inherited mutation in the MMR gene, K-ras mutation is frequent, and most arise from villous adenomas. In sporadic colorectal cancers, MMR errors are due to epigenetic
silencing of the MMR gene MLH1, the BRAF-V600E mutation is frequent, and most arise from the serrated-polyp pathway. This article reviews the genetic, clinical, and pathologic
differences and similarities between these tumor types. |
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