儿童复发性呼吸道乳头状瘤病患儿T细胞亚群的变化研究

目的 分析儿童复发性呼吸道乳头状瘤病（Jo-RRP）患儿外周血T细胞亚群的变化并探讨其临床意义. 方法 40例Jo-RRP患儿为病例组,选择同期体检的20例儿童做健康对照组,采用流式细胞仪对Jo-RRP病例组、健康对照组外周血T细胞亚群进行检测,并分析患儿T细胞亚群的变化与疾病进程的相关性. 结果 Jo-RRP病例组CD3＋ T、CD4＋ T细胞百分率及CD2/CD8＋比值较健康对照组降低,差异有统计学意义（P＜0.05）. 结论 Jo-RRP患儿存在T细胞介导的免疫功能障碍,免疫功能降低在Jo-RRP的进程中起重要的作用.

Changes of T lymphocytes Subsets in peripheral blood of children with juvenile onset recurrent respiratory papillomatosis

Objetive To investigate the Changes of T lymphocytes Subsets in Peripheral Blood of children with juvenile-onset recurrent respiratory papillomatosis （Jo-RRP） and discuss the clinical significance.Methods forty patients of Jo-RRP counted as group A.Twenty healthy children who had physical examination during the same period were enrolled as the control group B.Flow cytometric analysis was employed to study T lymphocytes Subsets in Peripheral Blood of 40 children with Jo-RRP and 20 health control group.Results The percentage of CD3＋ T、CD4＋ T lymphocytes subsets and the ratio of CD4＋/CDs＋ of the Jo-RRP children （group A）were significantly lower than the healthy children （group B,P ＜ 0.05）.Conclusion T lymphocytes Subsets mediate the cellular immune function is depressed in children with Jo-RRP.Decrease of immunity function play important roles during the progress of Jo-RRP.