Mitchellenes A-E, cyclic sesquiterpenes from the Australian plant Eremophila mitchellii |
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Authors: | Barnes Emma C Carroll Anthony R Davis Rohan A |
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Institution: | Eskitis Institute, Griffith University, Brisbane, QLD 4111, Australia. |
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Abstract: | Chemical investigations of the Australian plant Eremophila mitchellii resulted in the isolation of the novel tetracyclic sesquiterpene lactones mitchellenes A-C (1-3), the new sesquiterpene acids mitchellenes D and E (4 and 5), and the previously reported natural products 14-hydroxy-6,12-muuroloadien-15-oic acid (6), casticin, and centaureidin. The chemical structures of all compounds were determined by extensive 1D/2D NMR and MS data analysis. Mitchellenes A-C are the first tetracyclic sesquiterpene lactones to be reported; a biosynthetic pathway is proposed for these unique secondary metabolites. |
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