卡马西平诱导大鼠骨髓抑制模型的建立

目的：建立卡马西平（CBZ）诱导的骨髓抑制大鼠模型.方法：SD大鼠72只,随机分为正常对照组和模型组.正常对照组12只,每d灌胃蒸馏水,其余不做任何处理.模型组60只,以CBZ灌胃,剂量由600 mg/kg始,每5 d增加200 mg/kg,至1 200 mg/kg维持,共计灌胃120 d,然后停用CBZ,继续观察30 d.于给药第30 d、60 d、90d、120 d及停药30 d后各取大鼠12只处死,观察外周血象、骨髓象的变化.结果：模型组大鼠一般情况差,给药60d后大鼠即开始表现全血抑制,其中红系造血母细胞的抑制更为明显.在CBZ撤除30 d内,造血系统功能未见明显恢复.结论：成功建立了CBZ诱导的骨髓抑制大鼠模型.

Establishment of rat bone marrow inhibition model induced by carbamazepine

Aim: To establish the model of rat bone marrow inhibition induced by carbamazepine tablets (CBZ).Methods: A total of 72 rats were randomly allocated into 2 groups.The model group(n=60) was given CBZ by gavage from a dose of 600 mg/kg and increased by 200 mg/kg every 5 d till increased to 1 200 mg/kg and mainained the dose till the end of administration. The normal control group(n=12) was given distilled water.On the 30th d,60th d,90th d,120th d,and 150th d,12 rats in model group and rats in normal control group on the 150th d were executed. The changes of peripheral hemogram and bone marrow matrix were observed.Results:The general condition of model group was bad and from the 60th d,the rats presented the whole blood inhibition, and the inhibition of hemocytoblast was more obvious.Within 30 d after the withdrawl of CBZ, the bone marrow function had no obvious recovery.Conclusion: The rat bone marrow inhibition model induced by CBZ is successfully established.