急性心肌梗死患者血清激素水平的变化及其临床意义

本文测定了21例急性心肌梗死（AMI）患者的血清甲状腺激素，胰岛素、胰高糖素、皮质醇、胃泌素和催乳素浓度并与正常对照组相比较，结果发现，AMI患者血清T3明显降低（P＜0．001），并与皮质醇浓度升高有显著的相关性（P＜0．05），T4，TSH无明显变化（P＞0．05）；胰高糖素、胃泌素、催乳素、皮质醇浓度均有意义地升高（P＜0．001），胰岛素无变化（P＞0.05）。有并发症的AMI组与无并发症AMI组两者相比，前者T3更降低（P＜0．01），说明AMI低T3与病变程度的预后有关。这些激素变化的可能机制是AMI在应激状态下机体的防御保护性反应。

Clinical Significance of Serum Hormones Changes in Patients with Acute Myocardial Infarction

Serum thyroid hormones, insulin, glucagon, cortisol, prolactin and gastrin in 21 patients with acute myocardial infarction (AMI) and 69 normal healthy persons were measured by radioimmunoassay. The results showed that: in comparison with normal control group, serum triiodothyronine (T3) was significantly low (P <0. 0001) and serum thyroxine (T4), thyroid stimulating hormone (TSH) and insulin did not change significantly (P > 0.05 ), but glucagon, cortisol, prolactin and gastrin were significantly e[evated in patients with AMI (P <0. 0001 ). Significant correlation was found between low T3 and high cortisol in patients with AMl (P <0.05). In addition, serum T3 was significantly lower in AMI patients with complications than in simple AMI patients, suggeesting low T3 syndroms during AMI was related to the degree of severity of the disease and was also of prognostic significance. These hormones change in patients with AMI may be a protective reaction to stress condition.