| 双链断裂修复基因rad52 rs11226多态与肿瘤易感性关联的Meta分析 |
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| 引用本文： | 何斐,蔡琳.双链断裂修复基因rad52 rs11226多态与肿瘤易感性关联的Meta分析[J].福建医科大学学报,2010,44(3):194-198. |
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| 作者姓名： | 何斐 蔡琳 |
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| 作者单位： | 福建医科大学,公共卫生学院流行病与卫生统计学系,福州,350004 |
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| 基金项目： | 国家自然科学基金，福建省科技开发计划资助项目，福建省教育厅科技项目 |
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| 摘 要： | 目的综合评价rad52 rs11226（C〉T）与癌症发病风险的关联。方法全面检索文献,对单核苷酸多态性位点rad52 rs11226与肿瘤关联的病例-对照研究结果进行Meta分析,并进行肿瘤类型和人群的亚组分析。结果共7篇文献纳入Meta分析,累计病例5 915例,对照10 992例。rad52 C等位基因相对于T等位基因导致肿瘤发病的OR值为0.94（95%CI：0.86-1.04,P=0.24）,差别无统计学意义。结论尚无证据说明rad52 rs11226（C〉T）多态与肿瘤易感性有关联,但仍需进一步探讨基因-基因和基因-环境的交互作用。
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| 关 键 词： | meta分析（主题） 基因 肿瘤 多态性 单核苷酸 |
Genetic Polymorphism of rad52 rs11226 and Cancer Risk:A Meta-analysis |
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| HE Fei,CAI Lin.Genetic Polymorphism of rad52 rs11226 and Cancer Risk:A Meta-analysis[J].Journal of Fujian Medical University,2010,44(3):194-198. |
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| Authors: | HE Fei CAI Lin |
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| Institution: | HE Fei,CAI Lin Department of Epidemiology & Biostatistics,School of Public Health,Fujian Medical University,Fuzhou 350004,China |
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| Abstract: | Objective To evaluate the association between genetic polymorphism of rad52 rs11226 and cancer risk.Methods A comprehensive search was conducted to identify all case-control studies of the relationship between polymorphism of rad52 rs11226 and cancer risk by meta-analysis.Two subgroups were studied in terms of cancer type and ethnicity.Results Seven eligible reports were identified,concerning 5 915 cancer cases and 10 992 controls.The pooled OR of C allele compared with that of T allele was 0.94(95%CI: 0.86... |
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| Keywords: | meta-analysis as topic genes neoplasms polymorphism single nucleotide |
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