| 丙型肝炎患者血清TNF,IL-6,IL-10及其临床意义 |
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| 引用本文： | 郑洁,李红,王玉平,高勇.丙型肝炎患者血清TNF,IL-6,IL-10及其临床意义[J].放射免疫学杂志,2004,17(6):440-441. |
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| 作者姓名： | 郑洁 李红 王玉平 高勇 |
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| 作者单位： | 江苏省徐州市红十字中心血站,221006;江苏省徐州市红十字中心血站,221006;江苏省徐州市红十字中心血站,221006;江苏省徐州市红十字中心血站,221006 |
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| 摘 要： | 目的 :探讨了丙型肝炎患者血清中TNF、IL - 6、IL - 10水平及意义。方法 :分别应用ELISA法和放免法检测了 5 8例丙型肝炎患者血清中TNF、IL - 6、IL - 10水平 ,并与 35名正常健康人作比较。结果 :丙型肝炎患者血清中TNF、IL - 6、IL - 10水平均非常显著地高于正常人水平 (P <0 .0 1) ,肝硬化组为甚 ,且TNF与IL - 6、IL - 10呈正相关 (r =0 .6 135 ,0 .6 2 2 5 ,P <0 .0 1)。结论 :TNF、IL - 6、IL - 10在丙型肝炎病毒感染的致病机理中有一定的临床价值。
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| 关 键 词： | 丙型肝炎 白细胞介素-6 白细胞介素-10 |
| 修稿时间： | 2004年10月10 |
Clinical Significance of Changes of Serum Tumor Necrosis Factor (TNF)and Interleukin -6(IL-6), Interleukin -10(IL-10) Levels in Patients with Hepatitis C |
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| Zheng Ji,Li Hong,Gao Yong,et al..Clinical Significance of Changes of Serum Tumor Necrosis Factor (TNF)and Interleukin -6(IL-6), Interleukin -10(IL-10) Levels in Patients with Hepatitis C[J].Journal of Radioimmanology,2004,17(6):440-441. |
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| Authors: | Zheng Ji Li Hong Gao Yong |
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| Abstract: | Objective To explore the significance of the changes of serum TNF, IL-6, IL-10 levels in patients with hepatitis C. Methods The concentrations of serum IL-6, IL-10 were detected with ELISA and TNF with RIA in 58 patients with hepatitis C and 35 controls. Results Serum TNF, IL-6, IL-10 levels were significantly higher in the patients than those in controls (P<0.01), especially in cirrhotics TNF levels were positively correlated with those of IL-6, IL-10 (r=0.6135, 0.6225, P<0.01). Conclusion TNF IL-6 and IL-10 probably played important role in the pathogenesis of HCV infections. |
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| Keywords: | Hepatitis C Tumor necrosis factor Interleukin-6 Interleukin-10 |
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