靶向Wnt信号通路在牙周炎治疗领域的研究现状

牙周炎是由菌斑细菌引起并最终导致牙周支持组织吸收的感染性疾病，其药物治疗主要分为抑制炎症反应和介导牙周组织修复两个方面。 Wnt信号通路是调控胚胎干细胞以及多种组织干细胞自我更新和分化的关键途径，被认为是生物体中最为重要的信号通路之一。一些研究显示，Wnt信号通路在牙周炎的发生和治疗中起到关键作用。本综述从牙周病炎症免疫反应和介导牙周膜细胞成骨分化两个方面介绍了近年来关于Wnt信号通路调控的研究成果，并比较了可能通过激活Wnt通路介导牙周膜细胞成骨分化的潜在药物，为靶向Wnt通路治疗牙周炎提供了依据。

Current status of targeting Wnt signaling pathways in periodontal therapy

The periodontitis disease caused by the infection of plaque bacteria is an infective disease which eventually lead to resorption of periodontal tissues. Nowadays, there are two kinds of chemical therapies for periodontitis： anti-inflammation and reconstruction of periodontal tissues. Wnt pathway is considered as one of the central pathways to regulate self-renewal and differentiation of embryonic and somatic stem cell. Recent studies have shown that Wnt pathway played a pivotal role in the pathogenesis and treatment of periodontitis. This review introduces the novel studies of the Wnt pathway in the regulation of immuno-inflammatory responses of periodontitis and the osteogenesis of periodontal ligament cells （PDLCs）. Moreover, the review compares potential medications that promoting osteogenesis of PDLCs through Wnt pathway, providing evidence of treatments targeting Wnt pathway in periodontitis.