康艾注射液联合放疗治疗中晚期食管癌的临床研究

目的探讨康艾注射液联合放疗治疗中晚期食管癌的临床疗效,并探讨其对患者免疫功能和生活质量的影响。方法2012年5月—2014年4月上海市闵行区中心医院收治的中晚期食管癌患者78例,随机分为对照组（39例）和治疗组（39例）,对照组采用放射治疗,治疗组在对照组的基础上给予康艾注射液60 mL加入250 mL生理盐水,静脉点滴,1次/d,4周为1疗程,两组均连续治疗2个疗程。治疗后,评价两组的疗效、生活质量、细胞免疫功能。结果治疗后,治疗组和对照组的总有效率分别为61.54%、56.41%,两组比较差异具有统计学意义（P〈0.05）;治疗组生活质量（QOL）评分提高率74.36%,对照组为43.59%;治疗组体质量好转率56.41%,对照组为33.33%,两组比较差异均具有统计学意义（P〈0.01）。治疗后,治疗组CD3＋、CD4＋、CD4＋/CD8＋、NK比例升高,CD8＋比例下降,治疗前后差异有统计学意义（P〈0.01）,治疗组这些观察指标与对照组相比差异有统计学意义（P〈0.01）;对照组各指标无明显变化,与治疗前相比差异无统计学意义。结论康艾注射液联合放疗治疗中晚期食管癌具有较好的临床疗效,可以提高患者的生活质量和体质量,减轻放疗的不良反应,具有较好的临床应用价值。

Clinical study of Kangai Injection combined with radiotherapy in treatment of advanced esophageal carcinoma

Objective To investigate the clinical efficacy of Kangai Injection combined with radiotherapy for advanced esophageal cancer and its effect on immune function and quality of life. Methods Patients with advanced esophageal cancer were randomly divided into control （39 cases） and treatment （39 cases） groups. Patients in the control group were given radiation therapy, and patients in the treatment group were iv administered with 60 mL Kangai Injection, adding 250 mL normal saline for iv drip, once daily, 4 weeks as one course. Two groups were continuous treated for two courses. After treatment, the treatment efficacy, quality of life, and cellular immunity function were evaluated. Results After treatment, the effective rates in the treatment and control groups were 61.54% and 56.41%, respectively, with significant difference between the two groups （P 〈 0.05）. The increasing rate of QOL in the treatment and control groups were 74.36% and 43.59%, while body weight improvement rates were 54.61% and 33.33%, and the difference was statistically significant between the two groups （P 〈 0.05）. After treatment, CD3~, CD4~, CD4~/CD8~, and NK of the treatment group increased, CD8~ decreased, with statistically significant difference before and after treatment （P 〈 0.01）. Those detection indexes were compared with control group, and difference was statistically significant （P 〈 0.01）. The indexes of control group were not changed, compared with those before the treatment, the differences had no statistically significance. Conclusion Kangai Injection can improve the quality of life and body weight and reduce toxicity, with good clinical application value for the treatment of advanced esophageal cancer.