| MYOCARDIAL ENZYME LEAKAGE AND SUCCINIC DEHYDROGENASE ACTIVITY OF MITOCHONDRIA CORRELATED WITH MORPHOLOGICAL CHANGES IN THE ANOXIC ISOLATED PERFUSED RAT HEART |
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| 作者姓名： | 荣烨之 温文虎 付良雄 韩玉升 |
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| 作者单位： | Department of Internal Medicine，Xinhua Hospital，SSMU，Shanghai，Department of Internal Medicine，Xinhua Hospital，SSMU，Shanghai，Department of Internal Medicine，Xinhua Hospital，SSMU，Shanghai，Department of Biophysics，Faculty of Basic Medical Science，SSMU，Shanghai |
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| 摘 要： | Langendorff isolated perfused rat heart system was used to study the myocardial enzyme leakage and succinic dehydrogenase activity of mitochondria, and to investigate their correlation with the morphological changes due to anoxia-induced injury. 84 male Wistar rats were used and divided into the aerobic control group and the anoxic group. Besides the mitochondrial structural changes and the myccardial cell menbrane permeabilily defects observed, the SDH activity of mitcchondria was reduced and the CPK release increased. The morphological, functional and biochemical changes in anoxic rat heart correlated with each other very well.
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MYOCARDIAL ENZYME LEAKAGE AND SUCCINIC DEHYDROGENASE ACTIVITY OF MITOCHONDRIA CORRELATED WITH MORPHOLOGICAL CHANGES IN THE ANOXIC ISOLATED PERFUSED RAT HEART |
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| Rong Yezhi Wen Wenhu Fu Lingxiong.MYOCARDIAL ENZYME LEAKAGE AND SUCCINIC DEHYDROGENASE ACTIVITY OF MITOCHONDRIA CORRELATED WITH MORPHOLOGICAL CHANGES IN THE ANOXIC ISOLATED PERFUSED RAT HEART[J].Journal of Shanghai Second Medical University(Foreign Language Edition),1987(1). |
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| Authors: | Rong Yezhi Wen Wenhu Fu Lingxiong |
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| Institution: | Rong Yezhi Wen Wenhu Fu Lingxiong Department of Internal Medicine,Xinhua Hospital,SSMU,Shanghai Han Yusheng Department of Biophysics,Faculty of Basic Medical Science,SSMU,Shanghai |
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| Abstract: | Langendorff isolated perfused rat heart system was used to study the myocardial enzyme leakage and succinic dehydrogenase activity of mitochondria, and to investigate their correlation with the morphological changes due to anoxia-induced injury. 84 male Wistar rats were used and divided into the aerobic control group and the anoxic group. Besides the mitochondrial structural changes and the myccardial cell menbrane permeabilily defects observed, the SDH activity of mitcchondria was reduced and the CPK release increased. The morphological, functional and biochemical changes in anoxic rat heart correlated with each other very well. |
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| Keywords: | myocardial enzyme succinic dehydrogenase mitochondria animal experiment electron microscopic observation |
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