| 内皮素受体与蛛网膜下腔出血 |
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| 引用本文： | 黄海鹰,林雪群. 内皮素受体与蛛网膜下腔出血[J]. 解剖科学进展, 2005, 11(1): 61-64,69 |
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| 作者姓名： | 黄海鹰 林雪群 |
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| 作者单位： | 江西医学院脑血管研究所,江西,南昌,330006;江西医学院脑血管研究所,江西,南昌,330006 |
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| 基金项目： | 卫生部科学基金资助项目(No:98-1-337)，江西省自然科学基金资助项目(No:0140023 |
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| 摘 要： | 蛛网膜下腔出血的主要并发症是脑血管痉挛,脑血管痉挛可引起颅内压升高、脑血流降低和脑灌注 压降低,甚至死亡。其发生机制可能与内皮素、内皮衍生收缩因子、内皮衍生舒张因子和一氧化氮等因子有关。本 文讨论了实验性蛛网膜下腔出血动物模型的制作方法,内皮素受体在蛛网膜下腔出血诱发脑血管痉挛中的作用。
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| 关 键 词： | 内皮素受体 蛛网膜下腔出血 并发症 脑血管痉挛 |
| 文章编号： | 1006-2947(2005)01-0061-04 |
| 修稿时间： | 2004-07-15 |
Endothelin Receptor and Subarachnoid Hemorrhage |
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| HUANG Hai-ying,LIN Xue-qun. Endothelin Receptor and Subarachnoid Hemorrhage[J]. Progress of Anatomical Sciences, 2005, 11(1): 61-64,69 |
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| Authors: | HUANG Hai-ying LIN Xue-qun |
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| Abstract: | The cerebral vasospasm is the main complication caused by subarachnoid hemorrhage, and may induce the elevation of the intracranial pressure, decrease of the cerebral blood flow and even death. The mechanism of the cerebral vasospasm may be related to endothelin, endothelin-derived constricting factor, endothelin-derived relaxating factor and nitric oxide. The author also discussed the methods of the animal model of the subarachnoid hemorrhage and the effect of endothelin receptor on the cerebral vasospasm caused by subarachnoid hemorrhage. |
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