电针对慢心率大鼠心率影响的实验研究

<正> 临床观察和动物实验证明,针刺有抗心律失常作用,临床发现冠心病病人常常伴有心律失常,而心律失常又往往是急性心肌梗死的早期重要合并症,因此研究心律失常及其针刺效应对进一步提高疗效有一定意义。而电针对慢心率作用的实验研究报道不多,本实验主要在大白鼠身上观察电针对慢心率的治疗作用,为探索针刺治疗慢心率机理的形态学研究提供实验依据。材料和方法选择成年、健康雌雄大白鼠54只,体重200～360克,要求每组实验动物性别相同,体重相近,实验分两批进行。第一批实验:共用大白鼠26只,其中电针组9只、非针组10

EXPERIMENTAL STUDY OF THE EFFECT OF ELECTROACUPUNCTURT ON THE RATS WITH SLOW HEART RATE

54 healthy, adult rats were divided into 2 parts; the first part: 26 rats were randomized into electroacupunre (discontinuously), non-acupun- cture and control group.The slow heart rate of animals was caused by propranolol (0.1mg).Discontinuous electroacupuneture was applied on po- ints "Neiguan" bilaterally for 40 minutes (intensity 6-8 volt, frequency 50 HZ). The changes of heart rate of animals were observed before and the different time after discontinuous electroacupuneture, and comparison of heart rates between two groups. The second part:27 rats were randomized into electroacupuncture (continuely), non-acupuncture and control. The parameters and period of electroacupuncture were the same as that of the first part of experiment. The electroacupuneture was given to the rats in acupuncture group continuously for 40 minutes, the comparison of heart rate between acupuncture and non-acupuncture group was observed. The experimental results in the first part demonstrated that propranolol had the effect of decrearing heart rate; the heart rate before injection was 345.80±8.80; that of 10 min and 50 min after injection was 254.60±5.35 and 195.00±25.12 respectvely, there was significant difference between them (P<0.01). The heart rate before acupuncture was 266.89±5.39, and that after discontinuous electroacupuncture for 10 min was 305.11±9.28; the mean value of heart rate was incresed to 330.00±10.72 after discontinuous electroacupuncture for 40 min. The comparison between these two groups was staticanlly significant (P<0.01). The heart rate of rats in disconti- nuous electroacupuncture group was significantly increased as compared with non-acupuncture group (P<0.01); there was no significant differe- nce between electroacupuncture and control group (P<0.05). These resu- lts indicated that discontinuous electroacupuncture at points "Neigtina" had the recovery effect on slow heart rate. The experimental results in the second part were showed that the effect of propranolol on heart rate was the same as that of the first part. The effect of continuous electroacupu- ncture on slow heart rate was consistent with that of discontinuous elec- troacupuncture, and the recovery effect of continuous electroacupuncture on slow heart rate was better than that of discontinuous electroacupunc- ture. The results mentioned above indicated that: 1. The electroacupuncture at points "Neiguan" had the regulative. effect on heart rate under certain parameters of electroacupuncture. 2. The recovery effect of slow heart rate was better in continuous electroacupuncture group than that of discontinuous electroacupuncture group. 3. The regution of electroacupunccture on heart rats might be related to the regulation of vegetative nerve of heart for improving myocardial function.