Calpain10基因多态性与维吾尔族2型糖尿病患者亲级关系的研究

目的 分析Calpain10基因UCSNP43和UCSNP44位点多态性与新疆维吾尔族2型糖尿病家系中小同亲级的相关性.方法 以新疆62个维吾尔族2型糖尿病核心家系为样本,采用PPAP(population and pedigree analysis programs)统计软件和Penrose法来研究其遗传方式;将75个新疆维吾尔族2型糖尿病家系一级亲和二级亲成员481人做两组比较分析,采用基因芯片方法 榆测UCSNP43和UCSNP44位点多态性,应用SPSS 13.0统计软件分析Calpain10基凶多态性是否在2型糖球病家系不同亲级关系存在差异.结果 (1)2型糖尿病家系一级亲的遗传度为0.578,二级关的遗传度为0.032;(2)一级和二级亲属之间Calpain10基因UCSNP43、UCSNP44基因型和等位基因频率分布差异均无统汁学意义(P<0.05);(3)Calpain10其因UCSNP43位点AA基因型携带者体重指数、空腹胰岛素水平较GG和GA基因型携带者高(P<0.05或P<0.01).结论 新疆维吾尔族2型精尿病的遗传度随着亲缘系数的降低析减小;UCSNP43位点AA基因携带者胰岛素抵抗程度较GG和AG型携带者高.

Relationship between Calpain10 gene polymorphisms and diabetes in familial type 2 diabetes mellitus of Uygur in Xinjiang

Objective To analyse the relationship between Calpain10 gene UCSNP43 and UCSNP44 poly morphisms and diabetes in familial type 2 diabetes mellitus of Uygur in Xinjiang.Methods Sixty-two Uygur type 2 diabetic families were enrolled.The polymorphisms of Calpain10 gene UCSNP43 and UCSNP44 were measured by SNP-stream of gene chip.Results (1) The heritability of the first degree relative and the second degree relative in Uygur familial type 2 diabetes were 0.578 and 0.032.(2)There was no difference between UCSNP43 and UCSNP44 polymorphisms of the first and second degree relatives in familial type 2 diabetes mellitus.(3)The carriers of USCNP43 AA genotype had higher body mass index and fasting insulin than GG and GA genotypes carriers.Conclu sion With the downgrading of the familial relationship,the heritability of type 2 diabetes mellitus was decreasing. The carriers of UCSNP43 AA genotype might have higher insulin resistance than those with GG and AG genotypes.