胃转流手术后GK大鼠血糖变化与摄食量及体质量的关系

目的 探讨胃转流术(GBP)后GK大鼠血糖水平与大鼠摄食量及体质量变化的关系.方法 建立GK大鼠GBP动物模型,于术前、术后1、4、8周检测GK大鼠空腹血糖、摄食量及体质量变化.结果 (1)与假手术组血糖(14.18±1.67)mmol/L比较,术后各实验组GK大鼠血糖明显下降(5.58±0.49)、(5.24±0.23)mmol/L,差异有统计学意义(P＜0.01).(2)与假手术组摄食量(13.00±1.50)g比较,GBP术后各实验组GK大鼠摄食量(13.15±1.43)、(12.97±1.57)g,无明显变化,差异无统计学意义(P＞0.05).(3)与假手术组体质量(418.60±16.67)g比较,GBP术后各实验组GK大鼠体质量(401.60±21.84)、(340.80±18.69)g无明显变化,差异无统计学意义(P＞0.05).(4)Ⅳ组GK大鼠死于营养不良.结论 GBP的降糖作用与术后摄食量的减少及体质量下降无关.

Relationship of plasma glucose concentration and food intake and body weight change of GK rats after gastric bypass

Objective To investigate the relationship of plasma glucose concentration and food intake and body weight change of GK rats after gastric bypass ( GBP). Methods The animal model of GBP operation was established in GK rats. In all animals, post-operative measurements of fasting glycemia, food intake and body weight were done at the 1 st, 4th, and 8th week after the operation. Results ( 1) Compared with the sham-operated group (14.18 ± 1.67) mmol/L, the level of plasma glucose concentration in GK rats was decreased after GBP [ (5.58 ± 0.49), (5.24 ± 0.23) mmol/L (P < 0.01) ]. ( 2 ) Compared with sham-operated group (13.00 ± 1.50) g, the food intake [ ( 13.15 ± 1.43) , (12.97 ± 1.57) g] in experimental group after GBP had no significant change (P >0.05 ). (3) Compared with sham-operated group (418.60 ± 16.67) g, the body weight in experimental groups after GBP [(401.60 ±21.84), (340.80 ± 18.69) g] had no significant change (P > 0.05 ). (4) The GK rate in IV group died from malnutrition. Conclusion Hypoglycemic effects of GBP in GK rats are independent to weight and food intake.