|
|||||
|
|
Experimental Validation of Longitudinal Speed of Sound Estimates in the Diagnosis of Hepatic Steatosis (Part II) |
|
| Authors: | Rebecca E. Zubajlo Alex Benjamin Joseph R. Grajo Kanakaraju Kaliannan Jing X. Kang Atul K. Bhan Kai E. Thomenius Brian W. Anthony Manish Dhyani Anthony E. Samir |
| Affiliation: | 2. Division of Abdominal Imaging, Department of Radiology, University of Florida College of Medicine, Gainesville, Florida, USA;3. Laboratory for Lipid Medicine and Technology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA;4. Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA;5. Center for Ultrasound Research and Translation Department of Radiology Massachusetts General Hospital, Boston, Massachusetts, USA |
| Abstract: | This study validates a non-invasive, quantitative technique to diagnose steatosis within tissue. The proposed method is based on two fundamental concepts: (i) the speed of sound in a fatty liver is lower than that in a healthy liver and (ii) the quality of an ultrasound image is maximized when the beamformer's speed of sound matches the speed in the medium under examination. The method uses image brightness and sharpness as quantitative image-quality metrics to predict the true sound speed and capture the effects of fat infiltration, while accounting for the transmission through subcutaneous fat. Ex vivo testing on sheep liver, mouse livers and tissue-mimicking phantoms indicated the technique's ability to predict the true speed of sound with errors less than 0.5% and to quantify the inverse correlation between fat content and speed of sound. |
| Keywords: | Quantitative Ultrasound Non-alcoholic fatty liver disease Beam formation Sharpness Brightness Fast Fourier transform Principal component analysis Subcutaneous Fat Sound speed corrections |
| 本文献已被 ScienceDirect 等数据库收录！ | |