围产因素与早产儿颅内出血的相关性研究

目的探讨围产期各种相关因素与早产儿颅内出血发病的关系。方法选择2000年1月至2004年6月91例早产儿颅内出血患儿,同时随机抽取同期住院治疗91例无颅内出血早产儿作对照组。采用单因素分析和逐步logistic回归分析的方法,筛选早产儿颅内出血发病的危险因素。结果18个相关因素中两组患儿有8个围产因素存在显著性差异,分别为孕周、出生体重、1分钟Apgar评分、胎盘异常、羊水异常、多胎、宫内窘迫和是否及时正确复苏;是早产儿颅内出血的易感因素。把这8个因素作为自变量引入逐步logistic回归模型进行多因素分析,表明孕周、出生体重、宫内窘迫和1分钟Apgar评分为早产儿颅内出血的危险因素。结论临床对孕周≤32周,出生体重低,有宫内窒息以及1分钟Apgar评分≤7分的早产儿应提高对其发生颅内出血可能的预见性,及早采取预防措施。

A Correlation Study Among Perinatal Factors And the Premature Infants with Intracranial Hemorrhage

Objective:To study the correlation between perinatal factors and premature infants with intracranial hemorrhage.Methods:91 premature infants with intracranial hemorrhage were selected and 91 premature infants were also selected at the same period as the control group.18 risk factors were listed and analyzed by the methods of single-factor analysis and logistic regression analysis.Results:After single-factor analysis,there were significant differences of 8 perinatal factors in two groups,including gestational age,birth weight,one-minute Apgar score,placenta,meconium,multiple gestation,fetal intrauterine distress,resuscitation.And gestational age,birth weight,fetal intrauterine distress and 1-minute Apgar score were the main risk factors with logistic regression analysis.Conclusions:Clinical doctors should improve the predictability of possibility of premature infants with low gestational age,low birth weight,fetal intrauterine distress and 1-minute Apgar score to have intracranial hemorrhage, and take preventive measure in early stage.