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| 抗三价流感病毒亚单位疫苗IgY防治小鼠流感病毒感染的实验研究 | |
| 引用本文： | 胡国柱,文珠,聂荣庆,张进,朱清仙. 抗三价流感病毒亚单位疫苗IgY防治小鼠流感病毒感染的实验研究[J]. 中国免疫学杂志, 2011, 27(11): 963-965. DOI: 10.3969/j.issn.1000-484X.2011.11.001 |
| 作者姓名： | 胡国柱 文珠 聂荣庆 张进 朱清仙 |
| 作者单位： | 1. 江西省人民医院临床医学研究所,南昌,330006 2. 江西省医学科学研究所血液研究室,南昌,330006 3. 江西省中医药研究院中心实验室,南昌,330077 4. 南昌大学医学院组织胚胎教研室,南昌,330006 |
| 基金项目： | 国家科技部"十一五"科技支撑计划 |
| 摘 要： | 目的:探讨抗三价流感病毒亚单位疫苗IgY(Immunoglobulin Yolk)预防及治疗流感病毒感染小鼠的作用。方法:建立A/fm/1/47(H1N1)流感小鼠模型;分5组,观察各组小鼠死亡率,脾、肺指数及肺指数抑制率。结果:0.2%抗三价流感病毒亚单位疫苗IgY于攻毒前24、6、1小时滴鼻3次显著地预防流感病毒致死率(30.0%),而攻毒后1、6、24小时分别滴鼻3次,此后每天滴鼻1次,持续5天,致死率为20.0%,两组与阳性对照组(致死率90.0%)、非特异性IgY预防和治疗组(致死率80.0%,70.0%)比较差异显著(P<0.01)。0.2%抗三价流感病毒亚单位疫苗IgY预防组和治疗组肺指数显著低于阳性对照组(P<0.05~0.01),其治疗组也低于非特异性IgY预防和治疗组(P<0.05)。结论:抗三价流感病毒亚单位疫苗IgY感染前后24小时内多次滴鼻能有效地预防和治疗流感病毒感染。 |
| 关 键 词： | 小鼠 IgY 三价流感病毒亚单位疫苗 预防 治疗 |
The experiment research of IgY against influenza virus trivalent subunits vaccine preventing and treating influenza virus infection in mice |
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| HU Guo-Zhu,WEN Zhu,NIE Rong-Qing,ZHANG Jin,ZHU Qing-Xian. The experiment research of IgY against influenza virus trivalent subunits vaccine preventing and treating influenza virus infection in mice[J]. Chinese Journal of Immunology, 2011, 27(11): 963-965. DOI: 10.3969/j.issn.1000-484X.2011.11.001 | |
| Authors: | HU Guo-Zhu WEN Zhu NIE Rong-Qing ZHANG Jin ZHU Qing-Xian |
| Affiliation: | HU Guo-Zhu,WEN Zhu,NIE Rong-Qing,ZHANG Jin,ZHU Qing-Xian.Institute of Clinical Medicial Sciences,Jiangxi Province People's Hospital,Nanchang 330006,China |
| Abstract: | Objective:To investigate the effect of IgY against influenza virus trivalent subunits vaccine on preventing and treating influenza virus infection in mice.Methods:The mice infected with A/fm/1/47(H1N1) influenza virus were modeled.The experiments were divided into 5 groups and the mortality rate of infected mice,spleen index,lung index and lung index inhibiting rate were observed.Results:The 0.2% IgY against influenza virus trivalent subunits vaccine by intranasal delivery remarkably prevented mice death fa... |
| Keywords: | Mice IgY Influenza virus trivalent subunits vaccine Prevention Cure |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |