不同剂量利巴韦林联合干扰素治疗慢性丙型肝炎快速及早期病毒学应答的疗效观察

目的观察不同剂量利巴韦林（Ribavirin）联合普通干扰素（INFα-1b）治疗慢性丙型肝炎（CHC）快速及早期病毒学应答的疗效。方法二组均应用INFα-1b治疗,对照组33例患者加用利巴韦林10mg/（kg.d）;治疗组35例患者加用利巴韦林15mg/（kg.d）,观察二组的快速病毒学应答（RVR）及早期病毒学应答（EVR）。结果对照组RVR、EVR病例数分别为7例（21.21%）、18例（54.55%）;治疗组RVR、EVR病例数分别为10例（28.57%）、30例（85.71%）。二组RVR差异无统计学意义,而EVR差异有统计学意义（P〈0.05）。结论利巴韦林15mg/（kg.d）联合INFα-1b治疗CHC,可提高EVR,进一步可预测提高持续病毒学应答（SVR）。

THE EFFICACY OF EARLY VIROLOGICAL RESPONSES OF COMBINATION DIFFERENT DOSES OF RIBAVIRIN AND INTERFERON IN THE TREATMENT OF CHRONIC HEPATITIS C

Objective To investigate the efficacy of early virological responses（EVR） and rapid virological responses（RVR） of combination different doses of ribavirin and interferon（INFα-1b） in the treatment of chronic hepatitis C.Methods The 33 cases in the control group were treated with ribavirin 10mg/kg.d,the 35 cases in the treated group were given ribavirin 15mg/kg.d,all of patients were treated with INFα-1b.The EVR and RVR were observed in two groups.Results The cases of RVR and EVR were 7 cases（21.21%）,18 cases（54.55%）,10 cases（28.57%） and 30 cases（85.71%）respectively in the control group and treated group.The incidence of EVR was higher in the treated group than that in the control group（P0.05）.Conclusion Ribavirin 15mg/kg.d and INFα-1b for the treatment of chronic hepatitis C is effective to increase EVR.Perhaps it can improve the sustained virological responses（SVR）.