| 紫杉醇联合顺铂治疗晚期非小细胞肺癌临床观察 |
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| 引用本文： | 王会敏,王明喜. 紫杉醇联合顺铂治疗晚期非小细胞肺癌临床观察[J]. 实用全科医学, 2011, 0(9): 1397-1398 |
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| 作者姓名： | 王会敏 王明喜 |
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| 作者单位： | 安徽省灵璧县人民医院肿瘤科;安徽省蚌埠医学院第一附属医院肿瘤内科; |
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| 摘 要： | 目的探讨紫杉醇联合顺铂治疗晚期非小细胞肺癌的临床疗效和不良反应。方法选择灵璧县人民医院收治的晚期非小细胞肺癌患者36例，所有患者第1天均给予紫杉醇175mg/m2，静脉滴注3h，第2～5天给予顺铂20mg／m2，静脉滴注，21d为一周期，化疗2个周期以上，然后按WHO标准评价疗效和不良反应。结果36例患者均可评价疗效，全组无CR，PR16例，sD15例，PD5例，总有效率（CR＋PR）为44．4％。初治组有效率为59．1％，复治组有效率为21．4％，两组间比较差异有统计学意义（P〈0．05）。主要的不良反应为骨髓抑制，肌肉酸痛，恶心呕吐，脱发等，其中白细胞下降发生率为61．1％，肌肉酸痛发生率为50．0％，恶心呕吐发生率为55．6％，脱发发生率为63．9％，患者均可耐受。结论紫杉醇联合顺铂治疗晚期非小细胞肺癌有较好疗效，不良反应轻，值得临床进一步推广应用。
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| 关 键 词： | 非小细胞肺癌 紫杉醇 顺铂 |
The Combination of Paclitaxel and Cisplatin in the Treatment of Advanced Non-small Cell Lung Cancer |
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| WANG Hui-min,WANG Ming-xi. The Combination of Paclitaxel and Cisplatin in the Treatment of Advanced Non-small Cell Lung Cancer[J]. Applied Journal Of General Practice, 2011, 0(9): 1397-1398 |
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| Authors: | WANG Hui-min WANG Ming-xi |
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| Affiliation: | WANG Hui-min,WANG Ming-xi.Department of Oncology,People's Hospital of Lingbi,Suzhou 234222,Anhui,China |
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| Abstract: | Objective To study the efficacy and toxicity of paclitaxel(PTX) and cisplatin(DDP) in the treatment of advanced non-small cell lung cancer(NSCLC).Methods A total 36 cases with advanced non-small cell lung cancer enrolled in the study.The chemotherapy regimen consisted of PTX 135 mg/m2 by intravenous in fusion for 3 hours on day 1,DDP 20 mg/m2 by intravenous infusion on day 2 to day 5.The patients were repeatedly treated every 21 days.The efficacy and toxicity were evaluated by standard of WHO more than 1 cy... |
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| Keywords: | Non-small cell lung cancer(NSCLC) paclitaxel Cisplatin |
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