紫杉醇与多烯紫杉醇

目的比较紫杉醇与多烯紫杉醇在药学特性及临床应用的差异,为临床合理应用两药提供依据。方法查阅分析相关文献资料,比较分析两药异同。结果紫杉醇与多烯紫杉醇在化学结构、药代动力学、药物相互作用、药物毒性及临床应用等方面有不同的特点。结论临床应用中应根据各自特点,注意合理使用。

Paclitaxel and docetaxel

Objective To provide the basis for the clinical application of paclitaxel and docetaxel,compare their differences on pharmacological profiles and patterns of clinical activity. Methods The literature of taxanes was analyzed. Results The two taxanes differed in structures,pharmacokinetic charateristics,drug interactions,toxicity and administrations. Conclusion The rational use of the two taxanes should be based on their differences.