系统性红斑狼疮患者免疫球蛋白轻链及补体B因子测定的临床意义

目的 探讨血清中免疫球蛋白轻链κ和λ含量、κ/λ比值以及补体B因子(PFB)含量的检测在系统性红斑狼疮(SLE)诊疗中的应用价值.方法 在特定蛋白仪上,采用免疫速率散射比浊法测定SLE患者及对照组血清中轻链κ和轻链λ、PFB含量,并计算κ/λ比值.结果与30例对照组比较,51例SLE患者血清中轻链κ[(16.51±6.27)g/L,P<0.01]和轻链λ[(10.30±4.35)g/L,P<0.01]均升高;κ/λ比值下降(1.60±0.32,P<0.01),PFB含量下降[(0.214±0.063)g/L,P<0.01].结论 血清中免疫球蛋白轻链κ和轻链λ含量、κ/λ比值及PFB含量检测对SLE的临床诊疗具有重要的意义.

Clinical value of detecting serum immunoglobulin light chain and factor B in patients with systemic lupus erythematosus

Objective To explore the clinical value of detecting concentration of serum immunoglobulin light chain κ,λ,the κ/λ ratio and the concentration of factor B（PFB） in diagnosing systemic lupus erythematosus（SLE）.Methods In given protein instrument,the immune rate nephelometry（IRN） was used to detect the serum immunoglobulin light chain κ,λ and PFB,then the ratio of κ and λ was calculated.Results Compared with 30 cases of the control group,light chain κ[（16.51±6.27）g/L,P0.01] and λ[（10.30±4.35）g/L,P0.01] in 51 cases of SLE group all were increased,the ratio of κ/λ was decreased（1.60±0.32,P0.01） and the concentration of PFB was reduced[（0.214±0.063） g/L,P0.01].Conclusion Detecting the serum immunoglobulin light chain κ,λ,the κ/λ ratio and PFB has highly clinical significance in diagnosing and curing SLE.