口服盐酸达克罗宁胶浆复合丙泊酚静注用于无痛胃镜检查中的临床观察

目的探讨口服盐酸达克罗宁胶浆复合丙泊酚静注用于无痛胃镜检查中的安全性和可行性。方法选择100例要求行无痛胃镜检查术的患者,ASA分级Ⅰ~Ⅱ级,随机分成对照组和观察组,每组50例。观察组先予检查前10~15 min口服盐酸达克罗宁胶浆10ml后在Narcotrend监测下靶控输注丙泊酚进行诱导,对照组直接在Narcotrend监测下靶控输注丙泊酚进行诱导。两组Narcotrend指数(Narcotrend index,NI)均维持在D2。观察并记录两组患者的血流动力学变化、不良反应、丙泊酚用量、手术时间及苏醒时间。结果观察组高血压、心动过速、呛咳呃逆、体动及呼吸抑制的发生率显著低于对照组(P0.05),在丙泊酚用量、手术时间及苏醒时间上比较观察组显著少于对照组(P0.05)。结论在无痛胃镜检查术中,于丙泊酚静脉麻醉的基础上,加服达克罗宁胶浆,血流动力学更平稳,可减少不良反应,减少丙泊酚总剂量,缩短手术时间及麻醉复苏时间,应用于胃镜检查术中安全有效可行。

The Clinical Observation of Dycionine Hydrochloride Mucilage Combined with Propofol in the Applica- tion of Painless Gastroscopy

Objective To investigate the safety and feasibility of dyclonine hydrochloride mucilage com- bined with propofol in painless gastroseopy. Methods One hundred ASA I ~ 1I patients undergoing pain- less gastroscopy were randomly divided into the control group （50 patients） and the observation group （50 pa- tients）. In the control group, anesthesia was induced and maintained with propofol given by TCI and monitored by Narcotrend. In the observation group, 10ml of dyclonine hydrochloride mucilage was given orally about 10 N 15min before the examination, then anesthesia was induced and maintained with propofol given by TC! and mo- nitored by Narcotrend. In both groups, the anesthesia was adjusted to achieve a Narcotrend level of D2. Chan- ges of hemodynamics and adverse reactions were recorded. The dosage of propofol and the time of operation and the recovery time of consciousness were also recorded. Results The incidence of hypertension, tachycardia, chocking cough hiccups, bodyment, and respiratory depression in the observation group was significantly lower than that in the control group （P 〈 0.05 ）. The dosage of propofol and the time of operation and the recovery time of consciousness in the observation group were significantly less than that of the control group（P 〈 0.05）. Conclusions Dyclonine hydrochloride mucilage combined with propofol in painless gastroscopy can contribute to reducing the dosage of propofol and shorting the time of consciousness recovery, and also can make the hemo- dynamic more smoothly, and reduce the adverse reactions. So it is proved of the effectiveness and safety of the dyclonine hydrochloride mucilage combined with propofol in painless gastroscopy.