Synovial sarcoma with radiological appearances of primitive neuroectodermal tumour/Ewing sarcoma: differentiation by molecular genetic studies |
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| Authors: | P. O’Donnell T. C. Diss J. Whelan A. M. Flanagan |
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| Affiliation: | (1) Department of Radiology, Royal National Orthopaedic Hospital NHS Trust, Brockley Hill, Stanmore, Middlesex, HA7 4LP, UK;(2) Department of Histopathology, University College Hospital, London, UK;(3) Meyerstein Institute of Oncology, University College Hospital, London, UK;(4) Department of Histopathology, Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK;(5) Institute of Orthopaedics, University College, London, UK |
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| Abstract: | Synovial sarcoma (SS) arises in soft tissues but may invade adjacent bone. We describe a case of SS presenting as aggressive lysis of the proximal ulna, the imaging of which suggested a primary bone lesion. Needle biopsy showed a ‘small round blue cell tumour’, and a primitive neuroectodermal tumour (PNET)/Ewing sarcoma was suggested on the basis of the imaging appearances. The definitive diagnosis of synovial sarcoma was made following molecular genetic studies, which demonstrated a fusion product incorporating the genes SYT and SSX1. The importance of correct diagnosis to guide appropriate management, and, therefore, the necessity for molecular genetic studies, is discussed. |
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| Keywords: | Synovial sarcoma Ulna Ewing sarcoma Molecular genetics |
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