糖尿病患者血浆降钙素基因相关肽、内皮素水平及临床意义

目的 :探讨无血管并发症的糖尿病 (DM)和糖尿病肾病 (DN)的降钙素基因相关肽 (CGRP)、内皮素 (ET)水平及其临床意义。方法 :对照组 43人 ,DM组 45例 ,DN组 40例 ,测定血浆 CGRP、 ET及血压。结果 :DM组的 CGRP比对照组、 DN组显著增高 (P <0 .0 1,P <0 .0 5 )。 DN组的 ET比对照组、 DM组显著增高 (P <0 .0 1,P <0 .0 1)。三组的血压 :DN组最高 ,DM组次之 ,对照组最低。对照组、 DM组的 CGRP与 ET正相关 ,DN组的 CGRP与 ET无显著相关。结论 :CGRP对血压的影响 ,在无血管并发症的 DM大于 DN。

Level and clinical significance of plasma calcitonin gene related peptides and endothelin in diabetic patients

Objective: To study level and clinical significance of plasma calcitonin gene related peptides (CGRP) and endothelin (ET) in patients with diabetes mellitus (DM) without blood vessel complication and in patients with diabetic nephropathy (DN).Methods: The plasma concentrations of CGRP, ET and blood pressure were measured in control group (43 subjects), DM group (45 cases) and DN group (40 eases). Results: CGRP of DM group showed significant elevation as compared with that of control group and DN group (P＜0.01,P＜0.05). ET of DN group showed significant elevation as compared with that of control group and DM group (P＜0.01,P＜0.01). Blood pressure of three group: DN group was higher, DM group was second, control group was lower.CGRP and ET were positively correlated in control group and DM group.CGRP and ET revealed no significant correlation in DN group.Conclusion: Blood pressure is influenced by the CGRP,in DM without blood vessel complication bigger than DN.