宫内发育迟缓患儿成年期患代谢综合征的研究进展

宫内发育迟缓(IUGR)又称小于胎龄儿(SGA),不仅影响近期健康,且对远期健康和生长发育具有重要影响,成年后2型糖尿病、肥胖、高血压、冠心病等代谢综合征的发病率明显增高。可能的机制是在生命早期个体对不利的刺激高度敏感,产生基因表达的异常,影响内分泌系统,从而对某些器官的结构或功能产生长期或永久性的影响。我们需从做好产前母体的营养与健康管理、小于胎龄儿出生后的系统管理、喂养选择纯母乳喂养等措施减少疾病的发生。

Progress in the study of metabolic syndrome in children with intrauterine growth retardation

Intrauterine growth retardation (IUGR),also known as the small for gestational age (SGA),not only affects the recent health and has an important influence on long-term health and growth development. They are more easy to get the metabolic syndrome such as adult metabolism of type 2 diabetes,obesity,hypertension,coronary heart disease. Possi-ble mechanism is produced in the early life of individual,is highly sensitive to adverse stimuli gene expression abnormalities which affecting the endocrine system,thus it have a long-term or permanent impact on the structure and function of some or-gans. We need to do more in prenatal maternal nutrition and health management,system management of SGA infants,pure breast feeding. Thus these could reduce the occurrence of metabolic syndrome.