薏柏痛风丸治疗湿热痹阻型痛风性关节炎的临床疗效观察

【目的】观察薏柏痛风丸内服治疗痛风性关节炎(GA)湿热痹阻证患者的临床疗效。【方法】将116例痛风性关节炎患者随机分为治疗组62例和对照组54例。治疗组给予薏柏痛风丸治疗,对照组急性期给予口服秋水仙碱和碳酸氢钠片治疗,缓解期给予苯溴马隆片治疗。以12周为1个疗程,观察2组临床疗效,比较2组治疗前后血中C反应蛋白(CRP)、白细胞计数(WBC)、血尿酸(UA)水平的变化情况。【结果】(1)治疗组和对照组的总有效率分别为93.55%和83.33%,治疗组疗效优于对照组,差异有统计学意义(P0.05)。(2)治疗后,2组患者的中医证候积分均较治疗前明显降低(P0.05),且治疗组的降低作用优于对照组(P0.05)。(3)治疗后,2组患者血中CRP、WBC、UA水平均有明显改善(P0.05),且治疗组在改善CRP方面优于对照组(P0.05),而在改善WBC、UA方面差异无统计学意义(P0.05)。【结论】薏柏痛风丸能有效改善湿热痹阻型痛风性关节炎患者的中医证候,迅速降低CRP水平,临床疗效显著。

Clinical Observation of Yibai Tongfeng Pills for Treatment of Gouty Arthritis with Damp-heat Obstruction

Objective To observe the therapeutic effect of oral use of Yibai Tongfeng Pills for the treatment ofgouty arthritis with damp-heat obstruction. Methods One hundred and sixteen gouty arthritis patients were randomized into treatment group (N = 62) and control group (N = 54). The treatment group was treated with Yibai Tongfeng Pills orally, and the control group was treated with oral use of Colchicine Tablets and Sodium Bicarbonate Tablets at acute stage and with oral use of Benzbromarone Tablets at remission stage. Twelve weeks constituted one treatment course. Clinical efficacy of the two groups was evaluated after treatment, and the changes of C-reactive protein(CRP), white blood cell(WBC) and uric acid(UA) levels in the blood of the two groups were observed before and after treatment. Results (1) The total effective rate of the treatment group was 93.55%and that of the control group was 83.33%, the difference being significant(P<0.05).(2) After treatment, the scores of syndrome manifestations of the two groups were obviously decreased(P < 0.05 compared with those before treatment), and the decrease in the treatment group was superior to that in the control group(P<0.05) . (3) After treatment, CRP, WBC and UA levels in the blood of the two groups were much improved(P < 0.05 compared with those before treatment), and the improvement of CRP in the treatment group was superior to that in the control group(P<0.05), while the differences of the improvement of WBC and UA between the two groups were insignificant (P > 0.05). Conclusion Yibai Tongfeng Pills are effective for the treatment of gouty arthritis with damp-heat obstruction by improving syndrome manifestations and rapidly decreasing CRP level.