| 应用组织芯片研究Pim-3、p-STAT3在胰腺癌中的表达及临床意义 |
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| 引用本文： | 董赟,冯一中,李峰.应用组织芯片研究Pim-3、p-STAT3在胰腺癌中的表达及临床意义[J].临床与实验病理学杂志,2008,24(3). |
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| 作者姓名： | 董赟 冯一中 李峰 |
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| 作者单位： | 苏州大学附属第二医院病理科,苏州,215004 |
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| 摘 要： | 目的 探讨Pim-3、p-STAT3蛋白在胰腺导管腺癌组织中的表达情况及生物学行为意义.方法 应用组织芯片和免疫组化的方法,检测88例人胰腺导管腺癌组织和11例非癌组织中Pim-3、p-STAT3蛋白的表达,并分析其与临床病理特征及患者预后的关系.结果 在88例胰腺癌组织中Pim-3、p-STAT3的阳性表达率分别为76.1%和75.0%,在非癌胰腺组织内均为阴性表达.Pim-3在肿瘤细胞的胞质内表达,p-STAT3在肿瘤细胞的胞核与胞质内表达,两者的表达与胰腺癌的临床分期、淋巴结转移相关(P<0.01),与患者年龄、性别、肿瘤大小、位置和病理学分级无关(P>0.05),且其之间成正相关(r=0.416,P<0.01).Kaplan-Meier生存分析结果显示,胰腺癌组织中Pim-3、p-STAT3表达阳性的患者生存时间缩短.Cox多因素相关分析表明Pim-3和p-STAT3阳性表达是影响患者生存期的独立预后因素(分别P=0.003和P=0.015).结论胰腺癌中Pim-3、p-STAT3的阳性表达与肿瘤临床分期和淋巴结转移密切相关,且两者均可作为胰腺癌患者预后不良的判断因子.
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| 关 键 词： | 胰腺肿瘤 组织芯片 免疫组织化学 |
Expression and clinical significance of pim-3 and p-STAT3 in pancreatic cancer with tissue microarray |
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| DONG Yun,FENG Yi-zhong,LI Feng.Expression and clinical significance of pim-3 and p-STAT3 in pancreatic cancer with tissue microarray[J].Chinese Journal of Clinical and Experimental Pathology,2008,24(3). |
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| Authors: | DONG Yun FENG Yi-zhong LI Feng |
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| Institution: | DONG Yun,FENG Yi-zhong,LI Feng (Department of Pathology,the Second Affiliated Hospital,Suchoow University,Suzhou 215004,China) |
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| Abstract: | Purpose To investigate the expression of Pim-3,phosphorylated STAT3(p-STAT3) protein in the pancreatic ductal adenocacinoma(PDAC),and to gain insight their biological significance in carcinogenesis of pancreatic carcinoma.Methods The expression of Pim-3,p-STAT3 protein was determined by tissue microarray and immunohistochemistry(IHC) in 88 cases of pancreatic carcinoma and 11 noncancerous tissues.The relationship between their expression and the clinicopathologic parameters,the survival time of the patients... |
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| Keywords: | Pim-3 p-STAT3 |
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