| 尿吡啶酚和脱氧吡啶酚在恶性肿瘤骨转移中的临床意义 |
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| 引用本文： | 邸立军,刘淑俊,宛凤玲,朱步东,聂军.尿吡啶酚和脱氧吡啶酚在恶性肿瘤骨转移中的临床意义[J].中国肿瘤临床,2000,27(7):521-523. |
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| 作者姓名： | 邸立军 刘淑俊 宛凤玲 朱步东 聂军 |
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| 作者单位： | 北京医科大学临床肿瘤学院,北京市,100036 |
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| 摘 要： | 目的：评价尿吡啶酚和脱氧吡啶酚对恶性肿瘤骨转移患者的临床意义。方法：采用ＥＬＩＳＡ方法检测了２６例限局性恶性肿瘤、３５例进展期肿瘤骨转移阴性和３４例骨转移阳性的尿吡啶酚和脱氧吡啶酚水平。结果：进展期肿瘤尿吡啶酚和脱氧吡啶酚水平明显高于限局性肿瘤（Ｐ〈０．０５）；进展期肿产瘤骨转移阳性尿吡啶酚和脱氧吡啶酚水症又明显高于骨转移阴性（Ｐ〈０．０５）。结论：尿吡啶酚和脱氧吡啶酚可以在评价进展期肿瘤骨转移和
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| 关 键 词： | 尿吡啶酚 脱吡啶酚 骨转移癌 恶性肿瘤 骨转移 |
Clinical Significance of Urinary Pyridinium Cross-links in Neoplastic Bone Disease |
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| Di Lijun Liu Shujun Wan Fengling et al. School of Oncology,Beijing Medical University,Beijing.Clinical Significance of Urinary Pyridinium Cross-links in Neoplastic Bone Disease[J].Chinese Journal of Clinical Oncology,2000,27(7):521-523. |
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| Authors: | Di Lijun Liu Shujun Wan Fengling School of Oncology Beijing Medical University Beijing |
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| Abstract: | Objective:To evaluate the clinical significance of pyridinoline (PYD) and deoxypyridinoline (DPD) in patients with cancer.Medthod:Urine pyridinoline and deoxypyridinline were measured by ELISA assay in 26 patients with local cancer and 69 advanced cancer patients with or without bone metastases.Result:Advanced cancer patients with or without bone metastases had significantly higher urine concentrations of PYD and DPD than those of local cancer patients.The concentrations of both cross-links were also significantly higher in advanced cancer patients with bone metastases than those without bone metastases.Conclusion:These findings suggest that the measurement of PYD and DPD in urine may be useful in assessing bone metastases and bone resorption in cancer patients. |
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| Keywords: | pyridinoline deoxypyridinoline bone metastases |
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