| 载脂蛋白E基因多态性与脑梗死的关系 |
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| 引用本文： | 朱励,崔天盆. 载脂蛋白E基因多态性与脑梗死的关系[J]. 血栓与止血学, 2002, 8(1): 14-15 |
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| 作者姓名： | 朱励 崔天盆 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院,武汉,430022 |
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| 摘 要： | 目的:探讨载脂蛋白E(apo E)外显子4基因多态性与湖北汉族人脑梗死的关系。方法:分别采用聚合酶涟反应(PCR)结合限制性片段长度多态性方法检测apo E基因多态性。结果:脑梗死apo E外显子4基因多态性与正常对照组相比差异有显著性(P<0.01)。结论:apo E外显子4基因可能是汉族人脑梗死的遗传危险因素。
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| 关 键 词： | 载脂蛋白E 脑梗死 基因多态性 聚合酶链反应 汉族人 遗传危险因素 |
| 文章编号： | 1009-6213(2002)01-014-02 |
| 修稿时间： | 2001-10-15 |
The Relation of Apolipoprotien E Gene Polymorphism Exist in Cerebral Infaction |
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| ZHU Li,CUI Tian-pengUnion Hospital,Tongji Medical College,Huazhong Science and Technology University Wuhan. The Relation of Apolipoprotien E Gene Polymorphism Exist in Cerebral Infaction[J]. Chinese Journal of Thrombosis and Hemostasis, 2002, 8(1): 14-15 |
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| Authors: | ZHU Li CUI Tian-pengUnion Hospital Tongji Medical College Huazhong Science Technology University Wuhan |
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| Affiliation: | ZHU Li,CUI Tian-pengUnion Hospital,Tongji Medical College,Huazhong Science and Technology University Wuhan 430022 |
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| Abstract: | Objective: To explore the relation of apolipoprotien E extron 4 gene polymorphism exist in cerebral infaction of the Han people in Hubei province. Methods: The gene polymorphism were measured by polymerase chain reaction(PCR) and restriction fragment length polymorphisms(RFLP) assay. Results: The extron 4 gene polymorphism of apolipoprotien E in patient with cerebral infaction was increased significantly than normal group(P<0.01). Conclusion: Apolipoprotien E extron 4 gene may be a hereditary rick factor for patient with cerebral infaction of the Han people. |
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| Keywords: | Apolipoprotien E Cerebral infaction Gene polymorphism |
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