基因多态性与复发性自然流产的相关性研究

复发性自然流产（recurrent spontaneous abortions,RSA）是指连续发生2次或2次以上流产者。RSA的病因复杂,包括胚胎染色体异常、免疫功能异常、黄体功能不足、感染、生殖道异常等。但目前仍有部分RSA患者病因及发病机制尚不清楚,遗传背景等因素的改变可能使部分人群易发生RSA[1]。近年来从免疫遗传角度提出了一些新的观点,认为RSA的发生与遗传有关。寻找RSA的易感基因或致病基因,从根本上阐明RSA的发病机理,是RSA治疗和预防的重要途径。

Study on the relationship between gene polymorphism and repeated spontaneous abortion

Repeated spontaneous abortion(RSA)refers to abortions that occurred in succession two or more than two.The causes of RSA are complicated,including chromosomal abnormality of embryos,abnormal immune functions,luteal insufficiency,infection,genitourinary tract anomaly and so on.But now there are still some etiology and pathogenesis of RSA which are not clear,changes in genetic background and other facters may cause part of populations prone to RSA.Rerrent years some new points are put forward from the perspective of Immunology and Genetics,considering the causes of RSA are related with hereditary.Trying to find out susceptibility gene or pathogenic gene and clarifying the pathogenesis of RSA fundamentally,is important to the RSA treatment and prevention.