老年男性骨质疏松患者血清胰淀素与骨密度及骨转换生化指标的关系

目的探讨老年男性骨质疏松患者血清胰淀素(Amylin)水平的变化及其与骨密度(BMD)及骨转换生化指标的关系。方法采用酶联免疫法(ELISA)测定89例老年男性骨质疏松患者和50例正常男性老年人血清Amylin、骨碱性磷酸酶(BAP)、骨钙素(BGP)、I型胶原氨基末端肽(NTX),采用美国NORLAND XR-46 Excell-plus双能X线骨密度测定仪分别测定正位腰椎(L2-L4)及左侧股骨颈BMD。结果老年男性骨质疏松患者正位腰椎及左侧股骨颈BMD、血清Amylin、BAP、BGP水平较正常男性老年人明显降低(均P<0.01),血清NTX水平较正常男性老年人明显升高(P<0.01)。老年男性骨质疏松患者血清Amylin水平与患者正位腰椎及左侧股骨颈BMD、血清BAP、BGP水平呈明显正相关(r=0.598,r=0.652,r=0.576,r=0.584,均P<0.01),与患者血清NTX水平呈明显负相关(r=-0.673,P<0.01)。结论血清胰淀素水平降低在老年男性骨质疏松的发病中可能发挥重要作用。

Relationship between serum amylin and bone mineral density and bone turnover biochemical markers in elderly male osteoporosis patients

Objective To explore the changes of serum amylin in elderly male osteoporosis patients and its relationship with bone mineral density and bone turnover biochemical markers.Methods Serum amylin,bone alkaline phosphatase(BAP),bone gla protein(BGP),and cross-linked N-telopeptides of type I Collagen(NTX) in 89 elderly male osteoporosis patients and 50 health elderly males were measured using ELISA,and the BMD of lumbar vertebrae 2-4(L2-L4) and the neck of the femur(Neck) were measured using dual energy X-ray absorptionetry.Results The results showed that BMD of the lumbar vertebrae 2-4 and the neck of the femur,serum amylin,BAP,and BGP in elderly male osteoporosis patients were significantly lower(P<0.01) than those in the heath elderly males.However,serum NTX in elderly male osteoporosis patients was significantly higher than that in the heath elderly males(P<0.01).Serum amylin in elderly male osteoporosis patients was positively associated with BMD of lumbar vertebrae 2-4,the neck of the femur,serum BAP,and serum BGP(r=0.598,0.652,0.576,0.584,P<0.01),respectively.However,serum amylin in elderly male osteoporosis patients was negatively associated with serum NTX(r=-0.673,P<0.01).Conclusion The decrease of serum amylin concentration may play an important role in the development of osteoporosis in the elderly males.