胰岛素样生长因子结合蛋白-1在妊娠41周引产预测中的应用

目的 :探讨宫颈分泌物中胰岛素样生长因子结合蛋白 - 1 ( IGFBP- 1 )的定性测定对妊娠 41周引产时机选择的指导作用。方法 :对 68例妊娠 41～ 41 +6 周孕妇宫颈分泌物中的胰岛素样生长因子结合蛋白 - 1进行定性测定 ,同时作宫颈 Bishop评分。阳性组与阴性组均立即行催产素引产。结果 :阳性组与阴性组 3d内催产素引产成功率分别是 1 0 0 %与 64% ,催产素引产 3d成功率分别是 88.37%和 5 0 .0 0 %。结论 :定性测定宫颈分泌物 IGFBP- 1能预测分娩时间 ,是妊娠 41周引产时机选择的有效指标

Application of insulin-like growth factor binding protein-1 in predication of induced labor in 41 weeks gestation

Objectives: To evaluate the predictive value of the cervical biochemical marker insulin-like growth factor binding protein-1 (IGFBP-1) in induced labor in 41 weeks gestation. Methods: IGFBP-1 samples in the cervical secrets of 68 cases at 41～41~ +6 gestational weeks were measured qualitatively. Bishop scores were taken simultaneously. Induced labor by pitocin was initiated in both positive group and negative group immediately after the samples were taken. Results: Successful deliver rates initiated by pitocin in positive and negative group were 100% and 64% respectively within 72 hours, and those were 88.37% and 50.00% respectively within 24 hours. The positive rate of IGFBP-1 had a positive correction with cervical ripe scaled by Bishop scores. Conclusions: Qualitative measure of IGFBP-1 in cervical secrets has predicative value in judgment of cervical ripping scale, predication of spontaneous deliver, and arrangement of initiation of induced labor at 41 gestational weeks.