| 慢性乙型肝炎、肝硬化患者血清瘦素测定及临床意义 |
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| 引用本文： | 俞红,谢青,周霞秋,秦爱兰,郭清.慢性乙型肝炎、肝硬化患者血清瘦素测定及临床意义[J].诊断学,2004,3(1):30-31. |
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| 作者姓名： | 俞红 谢青 周霞秋 秦爱兰 郭清 |
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| 作者单位： | 上海第二医科大学附属瑞金医院感染科，上海200025 |
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| 摘 要： | 目的：测定慢性乙型肝炎(CHB)、乙型肝炎后肝硬化(LC)患血清瘦素水平，并探讨其异常变化的临床意义。方法：采用酶联免疫吸附试验(ELISA)，测定79例CHB、77例LC患的血清瘦素水平，同时检测76名正常人血清瘦素水平作为对照。结果：与正常对照组比较，CHB和LC患，无论男女其血清瘦素水平均明显降低，且CHB患瘦素水平明显低于LC患。以上3组血清瘦素水平女性均高于男性。结论：CHB和LC患，不论肝功能异常程度如何，其血清瘦素水平均低于正常人，其原因与肝脏受病毒感染损伤、肝脏功能异常明显相关。
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| 关 键 词： | 慢性乙型肝炎 肝硬化 血清瘦素 测定 |
| 文章编号： | 1671-2870(2004)01-0030-02 |
| 修稿时间： | 2003年10月14 |
Detection of serum leptin in patients with chronic hepatitis B and liver cirrhosis |
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| YU Hong,XIE Qing,ZHOU Xia-qiu,QIN Ai-hua,GUO Qing.Detection of serum leptin in patients with chronic hepatitis B and liver cirrhosis[J].Journal of Diagnostics Concepts & Practice,2004,3(1):30-31. |
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| Authors: | YU Hong XIE Qing ZHOU Xia-qiu QIN Ai-hua GUO Qing |
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| Affiliation: | YU Hong,XIE Qing,ZHOU Xia-qiu,QIN Ai-hua,GUO Qing.Department of Infectious Diseases,Ruijin Hospital,Shang hai Second Medical University,Shanghai200025,China |
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| Abstract: | Objective To inves ti gate the relationship between serum leptin levels and the liver function.Methods Serum leptin levels were detected by ELISA in79patients with chronic hepatitis B,77with liver cirrhosis and76control subjects,and their results were compared.R esults Compared with controls,serum leptin levels were significantly de-creased in patients with chronic hepatitis B and cirrhosis.Moreover,the levels of serum leptin were much higher in female than those in male subjects in all the3groups .Conclusions Serum leptin levels in the patients with chronic hepatitis B or liv er cirrhosis are lower than those in the controls regardless their liver functio n impairment degree,which is associated with liver function impairment originate d from hepatitis virus infection. |
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| Keywords: | Leptin Chronic hepatitis B Liver cirr hosis |
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