| AMPA受体与癫痫的关系 |
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| 引用本文： | 冯冠青,赵世刚,刘罡.AMPA受体与癫痫的关系[J].医学综述,2007,13(3):180-182. |
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| 作者姓名： | 冯冠青 赵世刚 刘罡 |
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| 作者单位： | 内蒙古医学院第一附属医院神经内科,呼和浩特,010050 |
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| 摘 要： | 癫痫是一种常见的神经系统疾病,严重危害人类健康。α-氨基羟甲基恶唑丙酸(AM-PA)受体是一种游离型兴奋性谷氨酸受体,由GluR1~GluR4 4个亚单位组成,GluR2亚单位对Ca2+不通透。由于GluR2亚单位的表达天然AMPA受体通道对Ca2+不通透。在AMPA受体激活时,大量Ca2+内流导致神经损伤。AMPA受体对于癫痫发病机制的研究和治疗均有重要作用。
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| 关 键 词： | 癫痫 AMPA受体 GluR2亚单位 钙 离子 |
| 文章编号： | 1006-2084（2007）03-0180-03 |
| 收稿时间： | 2006-05-20 |
| 修稿时间： | 2007-01-11 |
Relationship Between AMPA Receptor and Epilepsy |
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| FENG Guan-qing,ZHAO Shi-gang,LIU Gang.Relationship Between AMPA Receptor and Epilepsy[J].Medical Recapitulate,2007,13(3):180-182. |
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| Authors: | FENG Guan-qing ZHAO Shi-gang LIU Gang |
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| Institution: | Department of Neurology, the First Hospital Affiliated to Inner Mongolia medical college, Huhhot 010050,China |
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| Abstract: | Epilepsy is a common disease of neurology,which seriously affects the health of human.AMPA receptor is a kind of ionotropic glutamate receptors with excitability,which is composed of four subunits(GluR1-GluR4),among which GluR2 is impermeable to calcium.The nature AMPA receptor is normally Ca~(2+) impermeable due to the expression of GluR2 subunit.When AMPA receptor is activated,lots of intracellular Ca~(2+)result in neurons injury.AMPA receptor has the important role in epilepsy about its pathogenesis study and therapy. |
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| Keywords: | Epilepsy AMPA receptor GluR2 subunit Calcium Iron |
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