Renal function and insulin resistance as determinants of plasma leptin levels in patients with NIDDM |
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Authors: | T Shoji Y Nishizawa M Emoto K Maekawa Y Hiura S Tanaka T Kawagishi Y Okuno H Morii |
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Institution: | (1) Second Department of Internal Medicine, Osaka City University Medical School, Japan, JP |
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Abstract: | Summary Plasma leptin level is known to correlate with the degree of obesity. To determine the influences of renal fuction and insulin
resistance on plasma leptin concentrations, we measured plasma leptin concentrations and performed the euglycaemic hyperinsulinaemic
clamp studies in 57 patients with non-insulin-dependent diabetes mellitus with a wide range of renal function. In simple regression
analyses, plasma leptin concentration showed significant positive correlations with percentage of body fat measured by dual
energy X-ray absorptiometry, body mass index, waist to hip ratio and fasting plasma insulin. Leptin level was higher in females
than males. Multiple regression analyses indicated that percent body fat, waist to hip ratio, plasma insulin, gender and renal
function (1/creatinine), but not insulin sensitivity, were significant and independent determinants of plasma leptin level.
These results suggest that plasma leptin level is regulated or affected by multiple factors including renal function. Insulin
resistance appeared to increase leptin levels indirectly by raising plasma insulin. Diabetologia (1997) 40: 676–679]
Received: 27 November 1996 and in revised form: 3 March 1997 |
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Keywords: | Leptin insulin body fat non-insulin-dependent diabetes mellitus renal function |
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