MRI-visible perivascular space volumes,sleep duration and daytime dysfunction in adults with cerebrovascular disease |
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| Affiliation: | 1. Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada;2. Psychological Clinical Science, University of Toronto Scarborough, ON, Canada;3. Queen''s University, Centre for Neuroscience Studies, Kingston, ON, Canada;4. Rotman Research Institute, Baycrest Health Sciences Centre, Toronto, ON, Canada;5. Department of Pharmacology & Toxicology, University of Toronto, Toronto, Canada;6. Thunder Bay Regional Health Research Institute, Thunder Bay, ON, Canada;7. Department of Medicine (Neurology), Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada;8. Stroke Outcomes and Decision Neuroscience Research Unit, Division of Neurology, St. Michael''s Hospital, University of Toronto, ON, Canada;9. Department of Medicine (Neurology), Sunnybrook Health Sciences Centre and University of Toronto, ON, Canada;10. Department of Medical Imaging, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, ON, Canada;11. Centre for Functional and Metabolic Mapping, Robarts Research Institute, Department of Medical Biophysics, University of Western Ontario, ON, Canada |
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| Abstract: | ObjectivesRecent studies suggest that interindividual genetic differences in glial-dependent CSF flow through the brain parenchyma, known as glymphatic flow, may trigger compensatory changes in human sleep physiology. In animal models, brain perivascular spaces are a critical conduit for glymphatic flow. We tested the hypothesis that MRI-visible PVS volumes, a putative marker of perivascular dysfunction, are associated with compensatory differences in real-world human sleep behavior.MethodsWe analyzed data from 152 cerebrovascular disease patients from the Ontario Neurodegenerative Disease Research Initiative (ONDRI). PVS volumes were measured using 3T-MRI. Self-reported total sleep time, time in bed, and daytime dysfunction were extracted from the Pittsburgh Sleep Quality Index.ResultsIndividuals with greater PVS volumes reported longer time in bed (+0.85 h per log10 proportion of intracranial volume (ICV) occupied by PVS, SE = 0.30, p = 0.006) and longer total sleep times (+0.70 h per log10 proportion of ICV occupied by PVS volume, SE = 0.33, p = 0.04), independent of vascular risk factors, sleep apnea, nocturnal sleep disturbance, depression, and global cognitive status. Further analyses suggested that the positive association between PVS volumes and total sleep time was mediated by greater time in bed. Moreover, despite having on average greater total sleep times, individuals with greater basal ganglia PVS volumes were more likely to report daytime dysfunction (OR 5.63 per log10 proportion of ICV occupied by PVS, 95% CI: 1.38–22.26, p = 0.018).ConclusionsIndividuals with greater PVS volumes spend more time in bed, resulting in greater total sleep time, which may represent a behavioral compensatory response to perivascular space dysfunction. |
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| Keywords: | Sleep quality Perivascular spaces Virchow-Robin Small vessel disease Vascular cognitive impairment Glymphatic system |
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