Forensic genetic polymorphisms of 16 X-STR loci in the Yunnan Miao population and their relationship to other Chinese groups |
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| Institution: | 1. School of Forensic Medicine, Kunming Medical University, Kunming, Yunnan Province, People’s Republic of China;2. Honghe Public Security Bureau, Honghe, Yunnan Province, People’s Republic of China;3. Judicial Expertise Center of Kunming Medical University, Kunming, Yunnan Province, People’s Republic of China;1. Private Academic Consultant, Bangkok Thailand;2. Honorary Professor, Dr DY Patil University, Pune, India;1. Institute of Forensic Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, 610041, China;2. Hainan Provincial Blood Center, Haikou, 570311, China;3. College of Computer Science, Sichuan University, Chengdu, 610065, China;1. School of Forensic Medicine, Kunming Medical University, Kunming, Yunnan Province, People’s Republic of China;2. Judicial Expertise Center of Kunming Medical University, Kunming, Yunnan Province, People’s Republic of China;1. Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, via Consolare Valeria, 1, 98125 Messina, Italy;2. Section of Legal Medicine, Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Via del Vespro, 129, 90127 Palermo, Italy;3. Department of Anatomy, Diagnostic Pathology, Legal Medicine Hygiene and Public Health, University of Catania, Catania, Italy;4. Department of Economics, Unit of Statistical and Mathematical Sciences, University of Messina, Via dei Verdi 75, 98122 Messina, Italy;5. Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, Gazzi, Messina 98125, Italy;1. Dipartimento di Scienze della Sanità Pubblica e Pediatriche – Sezione di Medicina Legale – “Università degli Studi di Torino”, corso Galileo Galilei 22, 10126 Torino, Italy;2. Department of Life Sciences and Systems Biology, UNITO, via Accademia Albertina 13, 10123 Turin, Italy;3. CIR Dental School, Department of Surgical Sciences UNITO, via Nizza 230, 10126 Turin, Italy;4. A.O.U. Città della Salute e della Scienza – Anatomia Patologica U, Sezione Materno-Fetale-Pediatrica, corso Bramante 88, 10126 Torino, Italy |
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| Abstract: | Allele frequencies for 16 X-chromosomal STR (X-STR) loci were obtained from a sample set of 440 unrelated Yunnan Miao individuals in China. A total of 117 alleles were observed in this group, with allele frequencies ranging from 0.0016 to 0.7565. The most informative marker for the studied population was DXS10134, with a polymorphism information content (PIC) of 0.8499, and the least polymorphic locus was DXS6810 (PIC = 0.3071). The power of discrimination (PD) varied from 0.4046 (DXS6800) to 0.8642 (DXS10134) in males and from 0.6188 (DXS6800) to 0.9673 (DXS10134) in females. The combined PDM and PDF were 0.999999989975990 and 0.999999999999949, respectively. The combined MECD and MECT were 0.999983301904059 and 0.999999915883733, respectively. Furthermore, population genetic structure investigation between the Yunnan Miao and 20 other populations using principal component analysis (PCA), multidimensional scaling plot (MDS), and neighboring-joining (NJ) phylogenetic tree analyses illustrated significant genetic difference between the Yunnan Miao and the other populations. This study is the first to provide X chromosome genetic polymorphism data of the Miao population in Yunnan Province and can be used as a supplementary reference to enrich the national database. |
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| Keywords: | Genetic polymorphisms Forensic parameters 17 X-STR Miao ethnic minority Yunnan Province |
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