Retinal applications of swept source optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) |
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| Institution: | 1. Retina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA;2. Harvard Retinal Imaging Lab, Boston, MA, USA;3. Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People''s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China;4. Eye Clinic, Department of Biomedical and Clinical Science “Luigi Sacco”, University of Milan, Italy;1. New England Eye Center, Tufts Medical Center, Boston, Massachusetts;2. Federal University of São Paulo, School of Medicine, São Paulo, Brazil;3. Department of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts;4. Federal University of Goiás, Goiânia, Brazil;5. Pattern Recognition Lab, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany;6. Erlangen Graduate School in Advanced Optical Technologies (SAOT), Erlangen, Germany;7. Praevium Research Inc, Santa Barbara, California;1. Retina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts;2. Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China;3. Harvard Retinal Imaging Lab, Boston, Massachusetts;4. Eye Center of Xiangya Hospital, Central South University, Changsha, Hunan, China;5. Wenzhou Medical University Affiliated Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China;6. Retina and Vitreous Service, Yale Eye Center, Department of Ophthalmology, Yale School of Medicine, New Haven, Connecticut;7. Boston University School of Medicine, Boston University, Boston, MA;1. Retina, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA;2. Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, Hunan, China;3. Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Boston, Massachusetts, USA;4. Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People''s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China;5. Boston University School of Medicine, Boston, Massachusetts, USA;6. Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, USA |
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| Abstract: | The advent of optical coherence tomography (OCT) revolutionized both clinical assessment and research of vitreoretinal conditions. Since then, extraordinary advances have been made in this imaging technology, including the relatively recent development of swept-source OCT (SS-OCT). SS-OCT enables a fast scan rate and utilizes a tunable swept laser, thus enabling the incorporation of longer wavelengths than conventional spectral-domain devices. These features enable imaging of larger areas with reduced motion artifact, and a better visualization of the choroidal vasculature, respectively. Building on the principles of OCT, swept-source OCT has also been applied to OCT angiography (SS-OCTA), thus enabling a non-invasive in depth-resolved imaging of the retinal and choroidal microvasculature. Despite their advantages, the widespread use of SS-OCT and SS-OCTA remains relatively limited.In this review, we summarize the technical details, advantages and limitations of SS-OCT and SS-OCTA, with a particular emphasis on their relevance for the study of retinal conditions. Additionally, we comprehensively review relevant studies performed to date to the study of retinal health and disease, and highlight current gaps in knowledge and opportunities to take advantage of swept source technology to improve our current understanding of many medical and surgical chorioretinal conditions. We anticipate that SS-OCT and SS-OCTA will continue to evolve rapidly, contributing to a paradigm shift to more widespread adoption of new imaging technology to clinical practice. |
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| Keywords: | Imaging Swept source Optical coherence tomography Optical coherence tomography angiography Retina Choroid Vitreous |
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