Altered insular functional connectivity in isolated REM sleep behavior disorder: a data-driven functional MRI study |
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| Affiliation: | 1. Department of Neurology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, South Korea;2. Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea;3. Department of Neuropsychiatry, Seoul National University Hospital, Seoul, South Korea;4. Department of Neurosurgery, Seoul National University Hospital, Seoul, South Korea;5. Department of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, South Korea;6. Department of Neurology, Ajou University School of Medicine, Suwon, South Korea;7. Rare Disease Center, Seoul National University Hospital, Seoul, South Korea;8. Protein Metabolism and Neuroscience Research Center, College of Medicine, Seoul National University, Seoul, South Korea |
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| Abstract: | ObjectiveFunctional connectivity (FC) changes can occur prior to structural changes. This study aimed to evaluate data-driven whole-brain FC associated with isolated rapid eye movement sleep behavior disorder (iRBD) using multivariate pattern analysis (MVPA).MethodsThis was a cross-sectional study of 50 polysomnography-confirmed iRBD patients and 20 age- and sex-matched controls. We used MVPA implemented in the connectome-MVPA CONN toolbox to identify data-driven seed regions for post hoc seed-to-voxel connectivity analysis. The association between FC changes and clinical characteristics, including cognition, depression, autonomic function, and daytime sleepiness, was evaluated.ResultsMVPA revealed one significant cluster located in the left posterior insular cortex. Seed-to-voxel FC analysis using the cluster as a seed showed significantly reduced FC with two clusters located in the precuneus in iRBD patients compared to the controls. The degree of FC was associated with the Montreal Cognitive Assessment-Korean version scores (r = 0.317, p = 0.025).ConclusionThis study emphasizes the insula as an important neural correlate associated with iRBD that was associated with cognitive function. |
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| Keywords: | REM sleep Behavior disorder Functional brain imaging Multivariate pattern analysis (MVPA) Neuroimaging Cognitive function |
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