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Biomarkers of laryngeal squamous cell carcinoma: a review
Affiliation:1. Department of Neuroscience DNS, Otolaryngology Section, University of Padova, Padova, Italy;2. Department of Neuroscience DNS, Audiology Unit, University of Padova, Treviso, Italy;3. Radiotherapy Unit, Veneto Institute of Oncology IOV–IRCCS, Padova, Italy;4. Department of Medicine DIMED, University of Padova, Padova, Italy;5. Department of Neuroscience DNS, Bioacoustics Research Laboratory, University of Padova, Padova, Italy
Abstract:Laryngeal carcinoma is the second common malignancy of the upper aerodigestive tract after lung cancer; in most cases is a squamous cell carcinoma, whose risk factors include tobacco smoking and alcohol consumption. Despite therapeutic progress, the five-year overall survival rate for this malignancy has remained nearly 50% and many patients already present metastasis at the time of diagnosis.To date, there are no tools that predict the evolution of laryngeal carcinoma: in this light, during the last years, many studies were planned with the aim to investigate the role played by different biomarkers expressed by larynx cancer, which can help make an early diagnosis, predict disease evolution and direct therapeutic choice. This review aims to summarize these markers and correlating them with disease evolution.
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