The effect of Origanum majorana tea on motor and non-motor symptoms in patients with idiopathic Parkinson's disease: A randomized controlled pilot study |
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| Institution: | 1. Metabolic Biophysics and Applied Pharmacology Laboratory, Faculty of Medicine Ibn El Jazzar Sousse, Sousse University, Tunisia;2. Neurology Department, Sahloul Teaching Hospital, Sousse, Tunisia;1. Department of Psychiatry, The Carver College of Medicine at the University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA;2. Department of Epidemiology, The College of Public Health at the University of Iowa, 145 N Riverside Drive, Iowa City, IA, 52242, USA;3. Department of Neurology, The Carver College of Medicine at the University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA;4. Stead Family Department of Pediatrics, The University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA, 52242, USA;5. Division of Pharmacy Practice and Sciences, The College of Pharmacy at the University of Iowa, 180 South Grand Avenue, Iowa City, IA, 52242, USA;1. Department of Neurology, Mayo Clinic, Rochester, MN, USA;2. Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA;3. Center for Sleep Medicine, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, USA;4. Department of Radiology, Mayo Clinic, Rochester, MN, USA;1. Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy;2. Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy;3. Neurorehabilitation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy;4. Neurophysiology Service, IRCCS San Raffaele Scientific Institute, Milan, Italy;5. Vita-Salute San Raffaele University, Milan, Italy;1. Department of Neurology, Warren Alpert Medical School of Brown University, Providence, RI, USA;2. Rhode Island Hospital, Providence, RI, USA;3. Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, USA;4. Butler Hospital, Providence, RI, USA;5. Department of Neurology, University of Rochester, Rochester, NY, USA;1. RWTH Aachen University, Department of Neurology, Aachen, Germany;2. JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Juelich Research Center GmbH and RWTH Aachen University, Aachen, Germany;3. Department of Neurology with Institute of Sleep Medicine and Neuromuscular Disease, University Hospital Muenster, Muenster, Germany;4. Medical University Innsbruck, Department of Neurology, Innsbruck, Austria;5. Division for Clinical Cognitive Sciences, Department of Neurology, University Hospital RWTH, Aachen, Germany;6. Institute for Neuroscience and Medicine (INM-4), Research Center Juelich GmbH, Germany |
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| Abstract: | AimsThe effect of Origanum majorana tea consumption on motor and non-motor symptoms was investigated in patients with idiopathic Parkinson's disease, measured by validated tools.MethodsSixty patients with idiopathic Parkinson's disease and under conventional medication were enrolled voluntarily in the study. All participants were randomized on double-blind to placebo or Origanum majorana. Clinical assessment with validated tools (UPDRSIII, NMSS, and BDI) was done before Origanum majorana or placebo consumption (Day 0) and at the end of the experiment (Day 30).ResultsThe treatment groups were similar at baseline on demographic and clinical variables. During the course of study, nine participants withdrew for reasons of noncompliance and inability to follow-up. Fifty-one participants completed the study. Upon completion of 30 days of treatment, Origanum majorana tea consumption did not decrease the UPDRSIII score (UPDRSIII] D0 = 18.76 ± 8.58, D30 = 16.52 ± 7.96, p = 0.069) at the p value was 0.07. However, a statistically significant improvement was noted in NMSS and BDI scores (p < 0.0001 and p < 0.0001, respectively). Assessment of the UPDRSIII, NMSS and BDI scores of the patients did not reflect any improvement with placebo. No side effect was detected during the study.ConclusionThese findings show improvement of depressive and non-motor signs in patients with Parkinson's disease in the group that consumed Origanum majorana tea in combination with conventional therapy. Improvement of motor signs may need an extended treatment period. However, more research with a large number of participants and lasting longer than 1 month is needed to argue these findings. |
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| Keywords: | UPDRSIII NMSS BDI Parkinson's disease |
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