Mutation analysis for 25 Y-STR markers in Japanese population |
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| Affiliation: | 1. Key Laboratory of Molecular Cytogenetics and Genetic Breeding of Heilongjiang Province, College of Life Science and Technology, Harbin Normal University, Harbin 150025, Heilongjiang, PR China;2. State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, 200433, PR China;3. Health GeneTech, Ningbo 315000, PR China;4. Department of Radiology, First Affiliated Hospital, Medical College of Shantou University, Shantou 515041, PR China;5. Criminal Justice College of China University of Political Science and Law, Beijing 100088, PR China;6. Department of Anthropology and Ethnology, Institute of Anthropology, National Institute for Data Science in Health and Medicine, and School of Life Sciences, Xiamen University, Xiamen 361005, PR China;1. Multi-Omics Innovative Research Center of Forensic Identification; Department of Forensic Genetics, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, People’s Republic of China;2. Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an 710049, People’s Republic of China;3. Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi’an Jiaotong University, Xi’an 710004, People’s Republic of China;1. Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, PR China;2. Guangdong Province Translational Forensic Medicine Engineering Technology Research Center, Sun Yat-sen University, Guangzhou 510080, PR China;3. The Second Clinical Medical school (Zhujiang Hospital), Southern Medical University, Guangzhou 510280, PR China;1. Institute for Medical Research, University of Belgrade, Belgrade, Serbia;2. Center for Forensic and Applied Molecular Genetics, Faculty of Biology, University of Belgrade, Belgrade, Serbia;3. Institute of Forensic Medicine, Clinical Center of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia;4. Institute for forensic medicine, criminology and medical deontology, Medical Faculty, University of St. Cyril and Methodius, Skopje, Macedonia;5. Faculty of Mathematics, University of Belgrade, Belgrade, Serbia;6. Institute of History, Belgrade, Serbia |
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| Abstract: | In this study, we analyzed DNA samples from 213 Japanese father son pairs with 25 Y-chromosome short tandem repeat (Y-STR) (DYS576, DYS389I, DYS635, DYS389II, DYS627, DYS460, DYS458, DYS19, YGATAH4, DYS448, DYS391, DYS456, DYS390, DYS438, DYS392, DYS518, DYS570, DYS437, DYS385, DYS449, DYS393, DYS439, DYS481, DYF387S1, and DYS533) markers using the Yfiler™ Plus PCR amplification kit. We calculated Y-STR mutation rates for each locus to evaluate the efficacy of the 25 Y-STR markers for paternity testing and forensic identification using samples from male relatives. Six rapidly mutating Y-STR markers (DYS576, DYS627, DYS518, DYS570, DYS449 and DYF387S1), previously reported to have high mutation rates (>1.0 × 10−2), are included in the 25 Y-STR markers, but our findings revealed that the mutation rates for all Y-STR markers except for DYS576 and DYS458 were lower than 1.0 × 10−2. Therefore, the use of these 25 Y-STR markers may be useful for forensic identification in the Japanese population. |
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| Keywords: | Y-STR Yfiler™ Plus Mutation rate Rapidly mutating Y-STR |
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