Analysis of differentially expressed proteins between HER2 positive and triple negative breast cancer and their prognostic significance |
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| Institution: | 1. Department of Breast Surgery, The First Affiliated Hospital of Xi''an Jiaotong University, Xi''an 710061, China;2. Department of Geriatric Endocrinology, The First Affiliated Hospital of Xi''an Jiaotong University, Xi''an 710061, China;1. Department of Pathology and Laboratory Medicine, University of Texas McGovern Medical School, Houston, TX 77030, USA;2. Department of Internal Medicine, University of Texas McGovern Medical School, Houston, TX 77030, USA;3. Department of Advanced Cardiopulmonary Therapies and Transplantation, Center for Advanced Heart Failure, University of Texas Health Science Center at Houston, Houston, TX 77030, USA;1. Scientific Research Center for Biomedicine, Faculty of Medicine, University of Ni?, Zoran ?in?i? Boulevard 81, 18000 Ni?, Serbia;2. Pathology and Pathological Anatomy Center – Clinical Center of Ni?, Zoran ?in?i? Boulevard 48, 18000 Ni?, Serbia.;1. Departments of Pathology, China-Japan Friendship Hospital, Beijing, China;2. Departments of Pathology, Peking Union Medical College Hospital, Beijing, China;3. Departments of Radiology, China-Japan Friendship Hospital, Beijing, China;4. Departments of Thoracic Surgery, China-Japan Friendship Hospital, Beijing, China;5. Departments of Respiratory and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China;1. Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA;2. Otolaryngology-Head and Neck Surgery, Medical College of Wisconsin, Milwaukee, WI, USA;3. Institute of Medical and Public Health Research, Ilia State University, Tbilisi, Georgia;1. Department of Pathology and Laboratory Medicine, Albany Medical Center, Albany, NY, USA;2. Department of Surgery, Albany Medical Center, Albany, NY, USA;3. Albany Medical College, Albany, NY, USA;4. Department of Pediatrics, Albany Medical Center, Albany, NY, USA |
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| Abstract: | Both triple negative breast cancer (TNBA) and HER2-positive breast cancer lack expression of estrogen receptor alpha (ER) and progesterone receptor (PR), while human epidermal growth factor receptor 2 (HER2) in TNBC is also negative. This study aimed to identify the differentially expressed proteins (DEPs) between TNBC and HER2-positive breast cancer and to improve understanding of their role in the prognosis of breast cancer. By analyzing the breast cancer data set in The Cancer Proteome Atlas (TCPA) database, 15 DEPs between TNBC and HER2-positive breast cancer were identified. GO and pathway enrichment analysis were performed on DEPs, and the protein–protein interaction (PPI) network was constructed. The overall survival (OS) analysis of the breast cancer protein dataset in the Kaplan-Meier plotter showed that low expression of ACC1 suggested a higher OS of HER2-positive breast cancer (HR = 5.34, P < 0.05) and TNBC (HR = 2.88, P < 0.05). And TNBC patients with high TBA1B (HR = 0.16, P < 0.01) or low INPP4B (HR = 3.47, P < 0.05) expression have a better prognosis. Our research provides new insights into the prognostic indicators of TNBC and HER2-positive breast cancer, which could be further studied. |
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