Cadmium significantly changes major morphometrical points and cardiovascular functional parameters during early development of zebrafish |
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| Institution: | 1. Department of Pathophysiology, Medical Faculty, University of Belgrade, Belgrade, Serbia;2. Faculty of Electronic Engineering, University of Nis, Nis, Serbia;1. Centre of Excellence in Marine Biology, University of Karachi, Karachi, 75270, Pakistan;2. Pakistan Council of Scientific and Industrial Research Laboratories Complex, Microbiology Section, Karachi, 75280, Pakistan;3. Food and Marine Resources Research Center, Pakistan Council of Scientific and Industrial Research Laboratories Complex, Karachi, 75280, Pakistan;4. Instituto de Ciências da Saúde, Universidade Paulista, Campus Jundiaí, São Paulo, Brazil;5. Laboratório de Manejo, Ecologia e Conservação Marinha, Instituto Oceanográfico, USP, São Paulo, Brazil;1. The Academician Workstation, Jiangxi University of Chinese Medicine, Nanchang 330004, Jiangxi, People''s Republic of China;2. Murui Biological Technology Co., Ltd. Suzhou Industrial Park, No 11 Jinpu road, Suzhou, 215000, Jiangsu, People''s Republic of China;1. University of Science and Technology of China, Hefei, 230026, People’s Republic of China;2. CAS Key Laboratory of Biomedical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Science (CAS), 88 Keling Road, Suzhou, 215163, People’s Republic of China;1. School of Environmental Science and Safety Engineering, Tianjin University of Technology, Tianjin 300384, China;2. Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria, Tianjin Key Laboratory of Environmental Remediation and Pollution Control, Nankai University, Tianjin 300071, China;3. Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore |
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| Abstract: | Living organisms are commonly exposed to cadmium and other toxic metals. A vast body of research has shown the significant effects of these toxic metals on developmental processes. In order to study the role of toxic metals on early developmental stages of eukaryotes, we explored the effect of cadmium (Cd2+) contaminant on zebrafish. Thus, zebrafish embryos were exposed to 3 mg/L (16.7 μM) Cd2+ for 96 h and imaged every 24 h from the exposure onwards. Hatching rates of the eggs were determined at 72 h, followed by analyses at 96 h for: survival rate, morphometrical factors, and functional parameters of the cardiovascular system. Interestingly enough, significant hatching delays along with smaller cephalic region and some morphological abnormalities were observed in the treatment group. Moreover, substantial changes were noticed in the length of notochord and embryo, absorption of yolk sac with shorter extension, area of swimming bladder, as well as pericardium sac after Cd2+ treatment. Cadmium also caused significant abnormalities in heart physiology which could be the leading cause of mentioned morphological deformities. Herein, our results shine light on systematic acute embryological effects of cadmium in the early development of zebrafish for the first time. |
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| Keywords: | Cadmium Zebrafish embryo Toxicity Development |
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