Correlation between functional capacity and oxidative stress and inflammation in hemodialysis patients |
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| Institution: | 1. Medical Sciences Program, Universidade Federal Do Ceará- UFC, Brazil;2. Medical Sciences, Department of Clinical and Toxicological Analyses, Universidade Federal Do Ceará- UFC, Brazil;3. Pharmacology, Department of Clinical and Toxicological Analyses, Universidade Federal Do Ceará- UFC, Brazil;4. Nephrology, Professor of Universidade de Fortaleza- UNIFOR, Brazil;5. Pharmacology and Pharmaceutical Sciences of Universidade Federal Do Ceará- UFC, Brazil;6. Ph.D. in Medical Sciences, Professor of Physical Therapy Course, Department of Physical Therapy, Universidade Federal Do Ceará- UFC, Brazil;7. Inspirafisio Research Group, Universidade Federal Do Ceará- UFC, Brazil;1. Department of Physiotherapy, School of Paramedical Sciences, Mashhad University of Medical Sciences, Vakilabad Blvd, Bahonar Blvd, Pardis Campus, Mashhad, Iran;2. Orthopedic Research Center, Shahid Kamyab Hospital, Mashhad University of Medical Sciences, Mashhad, Iran;1. Federal University of Triangulo Mineiro, Uberaba, MG, Brazil;2. Department of Applied Physiotherapy, Federal University of Triangulo Mineiro, Uberaba, MG, Brazil;1. Laboratory of Physiotherapeutic Resources, Postgraduate Program in Rehabilitation and Functional Performance, University of São Paulo, Ribeirão Preto, SP, Brazil;2. Department of Biomechanics, Medicine and Rehabilitation, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, SP, Brazil;3. Department of Clinical Medicine, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil;1. Laboratório de Pesquisa do Exercício/ Universidade Federal do Rio Grande do Sul(UFRGS), Porto Alegre, RS, Brazil;1. Department of Physical Medicine and Rehabilitation, All India Institute of Medical Sciences, Gorakhpur, India;2. Department of Physical Medicine and Rehabilitation, All India Institute of Medical Sciences, New Delhi, India;3. Department of Physical Medicine and Rehabilitation, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, 249203, India;4. Department of Physiology, All India Institute of Medical Sciences, New Delhi, India |
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| Abstract: | IntroductionPatients with chronic kidney disease (CKD) may present impaired functional capacity due to peripheral muscle involvement. Oxidative stress and inflammation are probably involved in this pathophysiology. This study aimed to evaluate the association between functional capacity and biomarkers of oxidative stress as well as biomarkers of inflammation in patients under chronic hemodialysis therapy.MethodCross-sectional study including 41 patients from a single hemodialysis center. Functional capacity was assessed through the 6-min walk test (6MWT). The assessed blood biomarkers were: malondialdehyde (MDA) (oxidative stress, TBARS method) and angiopoietin-2 (Ang-2) (inflammation, ELISA). The influence of gender on impairment of functional capacity was further explored.ResultsThere was an inversely proportional correlation between the 6MWD and MDA (r = -,322 and p = 0.040) and Ang-2 (r = -, 376 and p = 0.016) values. 6MWD was 370.9 ± 101.2 m and 391.4 ± 108.2 m in women and men, respectively (p < 0.001), which means 29.3% and 34.3% reduction of the expected values for healthy individuals from the same age range.ConclusionPatients with CKD under hemodialysis, regardless of gender, presented impaired performance in 6MWT and this impairment was associated with oxidative stress and inflammation. |
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| Keywords: | Chronic kidney disease Renal dialysis Biomarkers 6-Min walk test |
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