Effect of gene-environment interaction (arsenic exposure - PON1 Q192R polymorphism) on cardiovascular disease biomarkers in Mexican population |
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| Affiliation: | 1. Molecular Diagnostics, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi 110085, India;2. Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi 110085, India;3. Rajiv Gandhi Cancer Institute and Research Centre, New Delhi 110085, India;1. The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang 550025, China;2. Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 211166, Jiangsu, China;3. The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, Jiangsu, China |
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| Abstract: | Cardiovascular diseases (CVDs) are the primary cause of death worldwide. However, little is known about how the interaction between risk factors affects CVDs. Therefore, the aim of this study was to evaluate the effect of the gene-environment interaction (arsenic exposure x PON1 Q192R polymorphism) on serum levels of CVDs biomarkers in Mexican women. Urinary arsenic levels (UAs) ranged from 5.50–145 μg/g creatinine. The allele frequency was 0.38 and 0.62 for the Q and R alleles, respectively. Moreover, significant associations (p<0.05) were detected between UAs and CVDs biomarkers (ADMA, FABP4, and miR-155). Comparable data were found when CVDs biomarkers were evaluated through PON1 genotype, significant (p<0.05) higher serum concentrations of CVDs biomarkers were identified in R allele carriers compared to levels found in Q allele carriers. Besides, a gene-environment interaction was documented. The results of this study we believe should be of significant interest to regulatory authorities worldwide. |
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| Keywords: | Arsenic ADMA FABP4 Gene-environment (GxE) interaction miRNAs Paraoxonase 1 |
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