Neural networks associated with quality of life in patients with Parkinson's disease |
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| Affiliation: | 1. Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, 89106, USA;2. University of Colorado, Boulder, CO, 80309, USA;3. Muhammad Ali Parkinson Center at Barrow Neurological Institute, Phoenix, AZ, USA;1. Department of Neurology, Kyungpook National University Hospital, Daegu, South Korea;2. Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea;3. Department of Neurology, Dongsan Medical Center, Keimyung University, Daegu, South Korea;4. Department of Neurology, Bobath Memorial Hospital, Seongnam, South Korea;5. Department of Neurology, Best Heals Hospital, Ansan, South Korea;6. Department of Neurology, Metro Hospital, Anyang, South Korea;7. Department of Neurology, The Good Light Hospital, Gwangju, South Korea |
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| Abstract: | IntroductionThe neural underpinnings of health-related quality of life in Parkinson's disease remain unclear. This study was conducted to unravel which motor and non-motor symptoms in Parkinson's disease influence health-related quality of life and reveal neural networks most likely linked to it.MethodsComprehensive clinical assessments were conducted for 247 Parkinson's disease patients and image analyses were performed for 181 patients. Clinical scores commonly used to assess various symptoms related to health-related quality of life were investigated. Factor and resting-state functional magnetic resonance imaging analyses were reviewed to reveal health-related quality of life-associated brain networks.ResultsThe Spearman's rank correlation coefficient for the Parkinson's disease Questionnaire-39 summary index was high in the Activities-specific Balance Confidence Scale, Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale part 2, Freezing of Gait Questionnaire, and Self-reported Autonomic Symptoms in Parkinson's disease. Multiple regression and Random Forest regression analyses indicated that health-related quality of life-associated factors were Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale part 1, Depression Rating Scales, and the above-mentioned scales. The resting-state functional magnetic resonance imaging analysis revealed decreased functional connectivity between the anterior cingulate cortex and right temporo-parietal junction as health-related quality of life worsened.ConclusionFear of falling, daily living activities, gait freezing, and autonomic dysfunction have notable effects on health-related quality of life in Parkinson's disease. Brain networks consisting of the anterior cingulate cortex and temporo-parietal junction may be associated with the emotion-related and social factors of health-related quality of life in Parkinson's disease. |
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| Keywords: | Quality of life Parkinson's disease Functional MRI Parkinson's disease Questionnaire-39 |
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